Literature DB >> 19959099

Thrombopoietin in normal and neoplastic stem cell development.

Kenneth Kaushansky1, Helen M Ranney.   

Abstract

It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V(617)F.

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Year:  2009        PMID： 19959099      PMCID： PMC2789277          DOI： 10.1016/j.beha.2009.08.004

Source DB:  PubMed          Journal:  Best Pract Res Clin Haematol        ISSN： 1521-6926            Impact factor:   3.020


  34 in total

1.  HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

Authors:  Jennifer Antonchuk; Guy Sauvageau; R Keith Humphries
Journal:  Cell       Date:  2002-04-05       Impact factor: 41.582

2.  Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

Authors:  P F Dijkers; R H Medema; C Pals; L Banerji; N S Thomas; E W Lam; B M Burgering; J A Raaijmakers; J W Lammers; L Koenderman; P J Coffer
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

3.  Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.

Authors:  A E Geddis; N E Fox; K Kaushansky
Journal:  J Biol Chem       Date:  2001-06-20       Impact factor: 5.157

Review 4.  Control of morphogenesis and differentiation by HOM/Hox genes.

Authors:  J Botas
Journal:  Curr Opin Cell Biol       Date:  1993-12       Impact factor: 8.382

5.  The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes.

Authors:  P Rojnuckarin; Y Miyakawa; N E Fox; J Deou; G Daum; K Kaushansky
Journal:  J Biol Chem       Date:  2001-09-04       Impact factor: 5.157

6.  Thrombopoietin expands hematopoietic stem cells after transplantation.

Authors:  Norma Fox; Greg Priestley; Thalia Papayannopoulou; Kenneth Kaushansky
Journal:  J Clin Invest       Date:  2002-08       Impact factor: 14.808

7.  Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells.

Authors:  Keita Kirito; Norma Fox; Kenneth Kaushansky
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

8.  Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.

Authors:  Keita Kirito; Norma Fox; Kenneth Kaushansky
Journal:  Blood       Date:  2003-07-10       Impact factor: 22.113

9.  Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species.

Authors:  Kozue Yoshida; Keita Kirito; Hu Yongzhen; Keiya Ozawa; Kenneth Kaushansky; Norio Komatsu
Journal:  Int J Hematol       Date:  2008-05-14       Impact factor: 2.490

10.  VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.

Authors:  Hans-Peter Gerber; Ajay K Malik; Gregg P Solar; Daniel Sherman; Xiao Huan Liang; Gloria Meng; Kyu Hong; James C Marsters; Napoleone Ferrara
Journal:  Nature       Date:  2002-06-27       Impact factor: 49.962
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  2 in total

1.  Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling.

Authors:  John Anto Pulikkan; Dmitri Madera; Liting Xue; Paul Bradley; Sean Francis Landrette; Ya-Huei Kuo; Saman Abbas; Lihua Julie Zhu; Peter Valk; Lucio Hernán Castilla
Journal:  Blood       Date:  2012-05-21       Impact factor: 22.113

2.  Immunophenotyping of Waldenströms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications.

Authors:  Aneel Paulus; Kasyapa S Chitta; Paul K Wallace; Pooja P Advani; Sharoon Akhtar; Maja Kuranz-Blake; Sikander Ailawadhi; Asher A Chanan-Khan
Journal:  PLoS One       Date:  2015-04-08       Impact factor: 3.240
  2 in total

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