| Literature DB >> 1995886 |
J A Lowe1, R L Archer, D S Chapin, J B Chen, D Helweg, J L Johnson, B K Koe, L A Lebel, P F Moore, J A Nielsen.
Abstract
A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models predictive of chronic diseases such as depression and inflammation. These results support the hypothesis that inhibition of CaIPDE may lead to useful activity in such chronic diseases.Entities:
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Year: 1991 PMID： 1995886 DOI： 10.1021/jm00106a024
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446