BACKGROUND: Food allergy is common, especially in childhood, where 6-8% of children are affected. Identification of early and efficient markers for later development of food allergy is very important. OBJECTIVE: We examined the ability of repeated measurements of food sensitization in early childhood to predict doctor-diagnosed food allergy (DDFA) at the age of 6 years. METHODS: The analysis was based on data from a prospective birth cohort study. Information was collected by parental questionnaires, and blood samples were obtained at 2 and 6 years of age. Children with repeated determination of sensitization to food allergens at 2 and 6 years of age were categorized into the sensitization phenotypes: no, early onset, late onset and persistent sensitization. The association between sensitization phenotypes and DDFA was prospectively investigated using multiple logistic regression analyses. RESULTS: Of 3097 children recruited at birth, a complete follow-up of IgE measurements and questionnaires at 1.5, 2 and 6 years were available for 1082 children. Early food allergen sensitization (fx5) was a strong risk for DDFA at 6 years [odds ratio (OR)=4.7; 95% confidence intervals (95% CI) 2.0-11.2] and for a new onset of DDFA at 6 years (OR=4.1; 95% CI 1.5-11.3). Additionally, persistent food allergen sensitization increased the risk of DDFA at 6 years (OR=6.1; 95% CI 2.7-13.7). Early sensitized children with a history of parental atopy showed the highest risk for DDFA at 6 years. CONCLUSION: Food-sensitized children during the first 2 years of life, especially with a family history of atopy, might be considered as a susceptible subgroup that requires specific attention concerning the development of food allergy-related symptoms.
BACKGROUND:Food allergy is common, especially in childhood, where 6-8% of children are affected. Identification of early and efficient markers for later development of food allergy is very important. OBJECTIVE: We examined the ability of repeated measurements of food sensitization in early childhood to predict doctor-diagnosed food allergy (DDFA) at the age of 6 years. METHODS: The analysis was based on data from a prospective birth cohort study. Information was collected by parental questionnaires, and blood samples were obtained at 2 and 6 years of age. Children with repeated determination of sensitization to food allergens at 2 and 6 years of age were categorized into the sensitization phenotypes: no, early onset, late onset and persistent sensitization. The association between sensitization phenotypes and DDFA was prospectively investigated using multiple logistic regression analyses. RESULTS: Of 3097 children recruited at birth, a complete follow-up of IgE measurements and questionnaires at 1.5, 2 and 6 years were available for 1082 children. Early food allergen sensitization (fx5) was a strong risk for DDFA at 6 years [odds ratio (OR)=4.7; 95% confidence intervals (95% CI) 2.0-11.2] and for a new onset of DDFA at 6 years (OR=4.1; 95% CI 1.5-11.3). Additionally, persistent food allergen sensitization increased the risk of DDFA at 6 years (OR=6.1; 95% CI 2.7-13.7). Early sensitized children with a history of parental atopy showed the highest risk for DDFA at 6 years. CONCLUSION: Food-sensitized children during the first 2 years of life, especially with a family history of atopy, might be considered as a susceptible subgroup that requires specific attention concerning the development of food allergy-related symptoms.
Authors: X Liu; G Wang; X Hong; D Wang; H-J Tsai; S Zhang; L Arguelles; R Kumar; H Wang; R Liu; Y Zhou; C Pearson; K Ortiz; R Schleimer; P G Holt; J Pongracic; H E Price; C Langman; X Wang Journal: Allergy Date: 2011-08-05 Impact factor: 13.146
Authors: Gabriele Kohlboeck; Marcel Romanos; Christina M Teuner; Rolf Holle; Carla M T Tiesler; Barbara Hoffmann; Beate Schaaf; Irina Lehmann; Olf Herbarth; Sibylle Koletzko; Carl-Peter Bauer; Andrea von Berg; Dietrich Berdel; Joachim Heinrich Journal: Eur Child Adolesc Psychiatry Date: 2013-12-11 Impact factor: 4.785
Authors: Kathleen Lee-Sarwar; Russ Hauser; Antonia M Calafat; Xiaoyun Ye; George T O'Connor; Megan Sandel; Leonard B Bacharier; Robert S Zeiger; Nancy Laranjo; Diane R Gold; Scott T Weiss; Augusto A Litonjua; Jessica H Savage Journal: J Allergy Clin Immunol Date: 2017-10-27 Impact factor: 10.793
Authors: Victor Turcanu; Helen A Brough; George Du Toit; Ru-Xin Foong; Tom Marrs; Alexandra F Santos; Gideon Lack Journal: Curr Opin Immunol Date: 2017-09-09 Impact factor: 7.486