Literature DB >> 19958277

Conformational stability and activity of circular Enterocin AS-48 derivatives.

Marina Sánchez-Hidalgo1, Ana M Fernández-Escamilla, Manuel Martínez-Bueno, Eva Valdivia, Luis Serrano, Mercedes Maqueda.   

Abstract

Four AS-48 mutants (Trp24Ala, Gly13Lys, Leu40Lys and Ala53Ser) were obtained by site-directed mutagenesis. The minimal inhibitory concentration of each peptide showed that only residue Trp24 was unquestionably involved in the biological activity. Guanidine hydrochloride-induced unfolding assays showed a three-state transition denaturation process, suggesting a molten-globule-like conformation after the first transition.

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Year:  2010        PMID： 19958277     DOI： 10.2174/092986610791190390

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  6 in total

Review 1.  AS-48 bacteriocin: close to perfection.

Authors:  Marina Sánchez-Hidalgo; Manuel Montalbán-López; Rubén Cebrián; Eva Valdivia; Manuel Martínez-Bueno; Mercedes Maqueda
Journal:  Cell Mol Life Sci       Date:  2011-05-17       Impact factor: 9.261

2.  Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401.

Authors:  Yoshimitsu Masuda; Hiroshi Ono; Hiroshi Kitagawa; Haruo Ito; Fuqin Mu; Naruhiko Sawa; Takeshi Zendo; Kenji Sonomoto
Journal:  Appl Environ Microbiol       Date:  2011-09-23       Impact factor: 4.792

3.  Insights into the functionality of the putative residues involved in enterocin AS-48 maturation.

Authors:  Rubén Cebrián; Mercedes Maqueda; José Luis Neira; Eva Valdivia; Manuel Martínez-Bueno; Manuel Montalbán-López
Journal:  Appl Environ Microbiol       Date:  2010-09-10       Impact factor: 4.792

4.  Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation.

Authors:  Florian Rohrbacher; André Zwicky; Jeffrey W Bode
Journal:  Chem Sci       Date:  2017-04-24       Impact factor: 9.825

5.  Bioinformatic prospecting and phylogenetic analysis reveals 94 undescribed circular bacteriocins and key motifs.

Authors:  Ben Vezina; Bernd H A Rehm; Andrew T Smith
Journal:  BMC Microbiol       Date:  2020-04-06       Impact factor: 3.605

6.  Crystal structure and site-directed mutagenesis of circular bacteriocin plantacyclin B21AG reveals cationic and aromatic residues important for antimicrobial activity.

Authors:  Mian-Chee Gor; Ben Vezina; Róisín M McMahon; Gordon J King; Santosh Panjikar; Bernd H A Rehm; Jennifer L Martin; Andrew T Smith
Journal:  Sci Rep       Date:  2020-10-15       Impact factor: 4.379
  6 in total

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