| Literature DB >> 19957208 |
Periasamy Meenakshi1, Rajendran Bhuvaneshwari, Muthaiyan Ahalliya Rathi, Lakshmanan Thirumoorthi, Dugganaboyana Chinna Guravaiah, Muthedath Janardhanan Jiji, Velliyur Kanniappan Gopalakrishnan.
Abstract
Diabetes mellitus is a complex disorder that disturbs the metabolism of carbohydrates, fats, and proteins. Medicinal plants play an important role in the management of diabetes mellitus. The present study was aimed to evaluate the antidiabetic potential of Zaleya decandra roots on alloxan-induced diabetes in rats. Oral administration of ethanolic extract of the root (200 mg/kg body weight/day) for 15 days restored the levels of glucose, cholesterol, triglycerides, total proteins, urea, creatinine, lipid peroxidation level, and antioxidant enzymes significantly in diabetic rats. Histopathological studies showed significant changes like necrosis and degeneration in the liver and pancreas of alloxan-induced diabetic rats. Also these histopathological abnormalities were found to be normalized after treatment with Z. decandra extract. The efficacy of the root extract was found to be equivalent when compared to the standard hypoglycemic drug glibenclamide (1.25 mg/kg body weight/day, orally) in diabetic rats.Entities:
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Year: 2009 PMID： 19957208 DOI： 10.1007/s12010-009-8871-x
Source DB: PubMed Journal: Appl Biochem Biotechnol ISSN： 0273-2289 Impact factor: 2.926