Literature DB >> 19956366

The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.

Eun-Kyoung Yim1, Jong-Sup Park.   

Abstract

Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.

Entities:  

Keywords:  Cervix neoplasms; E6; E7; Genomics; HPV; Proteomics

Year:  2005        PMID： 19956366      PMCID： PMC2785934          DOI： 10.4143/crt.2005.37.6.319

Source DB:  PubMed          Journal:  Cancer Res Treat        ISSN： 1598-2998            Impact factor:   4.679


  27 in total

1.  Livin, a novel inhibitor of apoptosis protein family member.

Authors:  G M Kasof; B C Gomes
Journal:  J Biol Chem       Date:  2000-10-09       Impact factor: 5.157

2.  Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.

Authors:  J M Walboomers; M V Jacobs; M M Manos; F X Bosch; J A Kummer; K V Shah; P J Snijders; J Peto; C J Meijer; N Muñoz
Journal:  J Pathol       Date:  1999-09       Impact factor: 7.996

3.  The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha.

Authors:  P Barnard; N A McMillan
Journal:  Virology       Date:  1999-07-05       Impact factor: 3.616

4.  Interaction of human Ku70 with TRF2.

Authors:  K Song; D Jung; Y Jung; S G Lee; I Lee
Journal:  FEBS Lett       Date:  2000-09-08       Impact factor: 4.124

5.  Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers.

Authors:  E Tokunaga; Y Maehara; E Oki; K Kitamura; Y Kakeji; S Ohno; K Sugimachi
Journal:  Cancer Lett       Date:  2000-04-28       Impact factor: 8.679

6.  BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

Authors:  E H Cheng; M C Wei; S Weiler; R A Flavell; T W Mak; T Lindsten; S J Korsmeyer
Journal:  Mol Cell       Date:  2001-09       Impact factor: 17.970

7.  A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.

Authors:  Isabella Versteege; Souhila Medjkane; Danny Rouillard; Olivier Delattre
Journal:  Oncogene       Date:  2002-09-19       Impact factor: 9.867

8.  Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation.

Authors:  T Crook; J A Tidy; K H Vousden
Journal:  Cell       Date:  1991-11-01       Impact factor: 41.582

9.  Protein profiling and identification of modulators regulated by the E7 oncogene in the C33A cell line by proteomics and genomics.

Authors:  Kyung-Ae Lee; Jung-Hyun Shim; Chang Won Kho; Sung Goo Park; Byoung Chul Park; Jae-Wha Kim; Jong-Seok Lim; Yong-Kyung Choe; Sang-Gi Paik; Do-Young Yoon
Journal:  Proteomics       Date:  2004-03       Impact factor: 3.984

10.  Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

Authors:  S Chellappan; V B Kraus; B Kroger; K Munger; P M Howley; W C Phelps; J R Nevins
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205
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  107 in total

Review 1.  Advances in technologies for cervical cancer detection in low-resource settings.

Authors:  Kathryn A Kundrod; Chelsey A Smith; Brady Hunt; Richard A Schwarz; Kathleen Schmeler; Rebecca Richards-Kortum
Journal:  Expert Rev Mol Diagn       Date:  2019-08-01       Impact factor: 5.225

2.  Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications.

Authors:  Anjelica Hodgson; Yutaka Amemiya; Arun Seth; Matthew Cesari; Bojana Djordjevic; Carlos Parra-Herran
Journal:  Mod Pathol       Date:  2017-07-21       Impact factor: 7.842

3.  Oral sarcoid in a cat.

Authors:  Sarah Greenwood; Olivier Campbell; Ahmad Reza Movasseghi
Journal:  Can Vet J       Date:  2019-05       Impact factor: 1.008

4.  Identification and characterization of an alternative cancer-derived PD-L1 splice variant.

Authors:  Nadia B Hassounah; Venkat S Malladi; Yi Huang; Samuel S Freeman; Ellen M Beauchamp; Shohei Koyama; Nicholas Souders; Sunil Martin; Glenn Dranoff; Kwok-Kin Wong; Chandra S Pedamallu; Peter S Hammerman; Esra A Akbay
Journal:  Cancer Immunol Immunother       Date:  2018-12-18       Impact factor: 6.968

5.  Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control.

Authors:  Yi-Hsin Lin; Ming-Chieh Yang; Ssu-Hsueh Tseng; Rosie Jiang; Andrew Yang; Emily Farmer; Shiwen Peng; Talia Henkle; Yung-Nien Chang; Chien-Fu Hung; T-C Wu
Journal:  Cancer Immunol Res       Date:  2018-01-23       Impact factor: 11.151

6.  ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer.

Authors:  Nam-Phuong D Nguyen; Viraj Deshpande; Jens Luebeck; Paul S Mischel; Vineet Bafna
Journal:  Nucleic Acids Res       Date:  2018-04-20       Impact factor: 16.971

7.  Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics.

Authors:  Patrick Herr; Johan Boström; Eric Rullman; Sean G Rudd; Mattias Vesterlund; Janne Lehtiö; Thomas Helleday; Gianluca Maddalo; Mikael Altun
Journal:  Mol Cell Proteomics       Date:  2020-02-12       Impact factor: 5.911

8.  Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.

Authors:  Jialing Zhang; Tony Chen; Xinping Yang; Hui Cheng; Stephan S Späth; Paul E Clavijo; Jianhong Chen; Christopher Silvin; Natalia Issaeva; Xiulan Su; Wendell G Yarbrough; Christina M Annunziata; Zhong Chen; Carter Van Waes
Journal:  Cancer Res       Date:  2018-06-19       Impact factor: 12.701

9.  Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.

Authors:  Daniel Henry Marks; Rozario Thomas; Yvette Chin; Riddhi Shah; Christine Khoo; Robert Benezra
Journal:  Cell Rep       Date:  2017-05-30       Impact factor: 9.423

10.  The Role of p53 Gene in Cervical Carcinogenesis.

Authors:  Sulekha Pandey; L K Pandey; A K Saxena; Nidhi Patel
Journal:  J Obstet Gynaecol India       Date:  2015-09-04
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