OBJECTIVE: To compare the risk status for lymph nodal metastasis at frozen section in endometrial cancer by applying a model based on tumor grade and myometrial involvement. STUDY DESIGN: A retrospective analysis was performed on 174 early-stage endometrial cancer patients on whom an intraoperative frozen section was requested. Patients were retrospectively divided into low, intermediate, and high risk for lymph nodal involvement based on tumor grade and myometrial invasion based on Gynecologic Oncology Group 33 data. Concordance of risk status at frozen and permanent sections was performed. RESULTS: Risk status at frozen and permanent sections were highly correlated (P < 0.01). Agreement between frozen and permanent sections was substantial (kappa = 0.625). In 16% of the cases, frozen section underestimated the risk when compared with permanent section. CONCLUSION: Relying on intraoperative frozen section of the uterus to assess risk status for lymph nodal involvement in early-stage endometrial cancer patients leads to suboptimal management in a substantial number of cases.
OBJECTIVE: To compare the risk status for lymph nodal metastasis at frozen section in endometrial cancer by applying a model based on tumor grade and myometrial involvement. STUDY DESIGN: A retrospective analysis was performed on 174 early-stage endometrial cancerpatients on whom an intraoperative frozen section was requested. Patients were retrospectively divided into low, intermediate, and high risk for lymph nodal involvement based on tumor grade and myometrial invasion based on Gynecologic Oncology Group 33 data. Concordance of risk status at frozen and permanent sections was performed. RESULTS: Risk status at frozen and permanent sections were highly correlated (P < 0.01). Agreement between frozen and permanent sections was substantial (kappa = 0.625). In 16% of the cases, frozen section underestimated the risk when compared with permanent section. CONCLUSION: Relying on intraoperative frozen section of the uterus to assess risk status for lymph nodal involvement in early-stage endometrial cancerpatients leads to suboptimal management in a substantial number of cases.
Authors: Maria Luisa Gasparri; Donatella Caserta; Pierluigi Benedetti Panici; Andrea Papadia; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2018-11-20 Impact factor: 4.553
Authors: Andrea Papadia; Maria Luisa Gasparri; Alessandro Buda; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2017-08-21 Impact factor: 4.553
Authors: Andrea Papadia; Maria Luisa Gasparri; Franziska Siegenthaler; Sara Imboden; Stefan Mohr; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2016-11-11 Impact factor: 4.553
Authors: Floor J Backes; Christopher J Walker; Paul J Goodfellow; Erinn M Hade; Garima Agarwal; David Mutch; David E Cohn; Adrian A Suarez Journal: Gynecol Oncol Date: 2016-03-10 Impact factor: 5.482
Authors: Andrea Papadia; Maria Luisa Gasparri; Anda P Radan; Chantal A L Stämpfli; Tilman T Rau; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2018-04-24 Impact factor: 4.553
Authors: Andrea Papadia; Alessandro Buda; Maria Luisa Gasparri; Giampaolo Di Martino; Beatrice Bussi; Debora Verri; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2018-07-24 Impact factor: 4.553
Authors: Andrea Papadia; Sara Imboden; Maria Luisa Gasparri; Franziska Siegenthaler; Anja Fink; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2016-06-18 Impact factor: 4.553
Authors: Andrea Papadia; Sara Imboden; Franziska Siegenthaler; Maria Luisa Gasparri; Stefan Mohr; Susanne Lanz; Michael D Mueller Journal: Ann Surg Oncol Date: 2016-01-20 Impact factor: 5.344