Literature DB >> 19955828

Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis.

Mysore K Phanish1, S K Winn, M E C Dockrell.   

Abstract

Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.

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Year:  2009        PMID： 19955828     DOI： 10.1159/000262316

Source DB:  PubMed          Journal:  Nephron Exp Nephrol        ISSN： 1660-2129


  76 in total

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Authors:  Joon-Il Jun; Lester F Lau
Journal:  Nat Rev Drug Discov       Date:  2011-12-01       Impact factor: 84.694

Review 2.  Cellular and molecular mechanisms of renal fibrosis.

Authors:  Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

Review 3.  Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.

Authors:  Ying Li; Yan Ge; Fu You Liu; You Ming Peng; Lin Sun; Jun Li; Qiong Chen; Yan Sun; Kun Ye
Journal:  Mol Cell Biochem       Date:  2011-09-29       Impact factor: 3.396

Review 4.  Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.

Authors:  Andrew J Sawyer; Themis R Kyriakides
Journal:  Adv Drug Deliv Rev       Date:  2016-01-04       Impact factor: 15.470

5.  Effects of Ganfukang on expression of connective tissue growth factor and focal adhesion kinase/protein kinase B signal pathway in hepatic fibrosis rats.

Authors:  Kun Zhang; Miao-na Jiang; Cai-hua Zhang; Cong Li; Yu-jie Jia
Journal:  Chin J Integr Med       Date:  2013-08-29       Impact factor: 1.978

6.  Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury.

Authors:  Rudolf Fuchshofer; Sabrina Ullmann; Ludwig F Zeilbeck; Matti Baumann; Benjamin Junglas; Ernst R Tamm
Journal:  Histochem Cell Biol       Date:  2011-08-04       Impact factor: 4.304

7.  Assessing the application of tissue microarray technology to kidney research.

Authors:  Ming-Zhi Zhang; Yinghao Su; Bing Yao; Wei Zheng; Mark Decaestecker; Raymond C Harris
Journal:  J Histochem Cytochem       Date:  2010-01-19       Impact factor: 2.479

8.  The C-terminal module IV of connective tissue growth factor, through EGFR/Nox1 signaling, activates the NF-κB pathway and proinflammatory factors in vascular smooth muscle cells.

Authors:  Raúl R Rodrigues-Diez; Ana Belen Garcia-Redondo; Macarena Orejudo; Raquel Rodrigues-Diez; Ana Maria Briones; Enrique Bosch-Panadero; Gyorgy Kery; Janos Pato; Alberto Ortiz; Mercedes Salaices; Jesus Egido; Marta Ruiz-Ortega
Journal:  Antioxid Redox Signal       Date:  2015-01-01       Impact factor: 8.401

9.  Renal findings in patients with Mulibrey nanism.

Authors:  Johanna Sivunen; Susann Karlberg; Jouko Lohi; Niklas Karlberg; Marita Lipsanen-Nyman; Hannu Jalanko
Journal:  Pediatr Nephrol       Date:  2017-04-22       Impact factor: 3.714

10.  LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca2+ Signaling and Expression of Cytoskeleton-Related Proteins.

Authors:  Dianaly T Au; Zhekang Ying; Erick O Hernández-Ochoa; William E Fondrie; Brian Hampton; Mary Migliorini; Rebeca Galisteo; Martin F Schneider; Alan Daugherty; Debra L Rateri; Dudley K Strickland; Selen C Muratoglu
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-11       Impact factor: 8.311
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