BACKGROUND: Few pathological data have focused on the causal link between intracranial atherosclerotic disease and parent artery stroke. The objective of this study was to investigate the cause of middle cerebral artery (MCA) atherosclerotic disease in patients with fatal stroke. METHODS AND RESULTS: In 123 patients with unilateral MCA territory infarction we performed a case-control autopsy study evaluating the frequency of atherosclerotic plaque and moderate (<70%) or severe (>or=70%) stenosis in the ipsilateral and contralateral MCA. Clinical history, risk factors, imaging data and general autopsy reports were available. The entire cerebral arterial tree was studied pathologically. MCA atherosclerosis (either moderate or severe stenosis) was more frequent in the ipsilateral (21.1%, n = 26) than the contralateral MCA (8.1%, n = 10). The corresponding odds ratio (OR) for the presence of atherosclerosis in the ipsilateral MCA relative to the contralateral MCA was 6.33 [95% confidence interval (CI) = 1.87-21.40]. This difference was found with both moderate (OR = 5.75, 95% CI = 1.45-22.76) and severe (OR = 7.18, 95% CI = 1.58-32.73) stenosis. CONCLUSIONS: Moderate MCA atherosclerotic stenosis may be responsible for parent territorial stroke. Novel arterial wall magnetic resonance imaging techniques should now be used to investigate in vivo the hypothesis that moderate MCA stenosis is a possible explanation in patients with nonfatal stroke of unknown cause. (c) 2009 S. Karger AG, Basel.
BACKGROUND: Few pathological data have focused on the causal link between intracranial atherosclerotic disease and parent artery stroke. The objective of this study was to investigate the cause of middle cerebral artery (MCA) atherosclerotic disease in patients with fatal stroke. METHODS AND RESULTS: In 123 patients with unilateral MCA territory infarction we performed a case-control autopsy study evaluating the frequency of atherosclerotic plaque and moderate (<70%) or severe (>or=70%) stenosis in the ipsilateral and contralateral MCA. Clinical history, risk factors, imaging data and general autopsy reports were available. The entire cerebral arterial tree was studied pathologically. MCA atherosclerosis (either moderate or severe stenosis) was more frequent in the ipsilateral (21.1%, n = 26) than the contralateral MCA (8.1%, n = 10). The corresponding odds ratio (OR) for the presence of atherosclerosis in the ipsilateral MCA relative to the contralateral MCA was 6.33 [95% confidence interval (CI) = 1.87-21.40]. This difference was found with both moderate (OR = 5.75, 95% CI = 1.45-22.76) and severe (OR = 7.18, 95% CI = 1.58-32.73) stenosis. CONCLUSIONS: Moderate MCA atherosclerotic stenosis may be responsible for parent territorial stroke. Novel arterial wall magnetic resonance imaging techniques should now be used to investigate in vivo the hypothesis that moderate MCA stenosis is a possible explanation in patients with nonfatal stroke of unknown cause. (c) 2009 S. Karger AG, Basel.
Authors: Jose Gutierrez; Mitchell S V Elkind; Renu Virmani; James Goldman; Lawrence Honig; Susan Morgello; Randolph S Marshall Journal: Int J Stroke Date: 2015-04-08 Impact factor: 5.266
Authors: Maria Khan; Asif Rasheed; Saman Hashmi; Moazzam Zaidi; Muhammad Murtaza; Saba Akhtar; Lajpat Bansari; Nabi Shah; Maria Samuel; Sadaf Raza; Umer Rais Khan; Bilal Ahmed; Bilawal Ahmed; Naveeduddin Ahmed; Jamal Ara; Tasnim Ahsan; S M Munir; Shoukat Ali; Khalid Mehmood; Karim Ullah Makki; Muhammad Masroor Ahmed; Niaz Sheikh; Abdul Rauf Memon; Philippe M Frossard; Ayeesha Kamran Kamal Journal: Int J Stroke Date: 2012-09-27 Impact factor: 5.266
Authors: Wen Jie Yang; Mark Fisher; Lu Zheng; Chun Bo Niu; Annlia Paganini-Hill; Hai Lu Zhao; Yun Xu; Ka Sing Wong; Ho Keung Ng; Xiang Yan Chen Journal: Front Neurol Date: 2017-09-25 Impact factor: 4.003