OBJECTIVE: To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF. DESIGN: Meta-analysis of observational studies. PATIENT(S): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis. MAIN OUTCOME MEASURE: Miscarriage risk ratio (RR). SECONDARY OUTCOME MEASURES: Clinical pregnancy rate and delivery rate. RESULT(S): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups. CONCLUSION: Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
OBJECTIVE: To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF. DESIGN: Meta-analysis of observational studies. PATIENT(S): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis. MAIN OUTCOME MEASURE: Miscarriage risk ratio (RR). SECONDARY OUTCOME MEASURES: Clinical pregnancy rate and delivery rate. RESULT(S): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups. CONCLUSION: Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
Authors: K Łukaszuk; M Kunicki; P Kulwikowska; J Liss; E Pastuszek; M Jaszczołt; B Męczekalski; K Skowroński Journal: J Endocrinol Invest Date: 2015-08-18 Impact factor: 4.256
Authors: David Unuane; Brigitte Velkeniers; Ellen Anckaert; Johan Schiettecatte; Herman Tournaye; Patrick Haentjens; Kris Poppe Journal: Thyroid Date: 2013-08 Impact factor: 6.568
Authors: Julian A Gingold; Kelly Zafman; Jorge Rodriguez-Purata; Michael C Whitehouse; Joseph A Lee; Benjamin Sandler; Alan B Copperman Journal: Gynecol Endocrinol Date: 2016-07-16 Impact factor: 2.260