Literature DB >> 19954974

Solid phase synthesis of 2-aminobenzothiazoles.

Francesco Piscitelli1, Carlo Ballatore, Amos B Smith.   

Abstract

A traceless solid supported protocol for the synthesis of 2-aminobenzothiazoles is described, employing resin-bound acyl-isothiocyanate and a series of anilines. Cyclization of the resulting N-acyl, N'-phenyl-thioureas generates the 2-aminobenzothiazole scaffold, which can be further elaborated prior to hydrazine-mediated cleavage of the final products from the carboxy-polystyrene resin. A small, focused library of 2-aminobenzothiazoles was prepared. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19954974      PMCID： PMC2818510          DOI： 10.1016/j.bmcl.2009.11.055

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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3.  Microwave-assisted synthesis of benzimidazoles, benzoxazoles, and benzothiazoles from resin-bound esters.

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  7 in total
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2.  Inhibition of tumor growth and angiogenesis by 2-(4-aminophenyl) benzothiazole in orthotopicglioma C6 rat model.

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