| Literature DB >> 19954970 |
Aranapakam M Venkatesan1, Christoph M Dehnhardt, Zecheng Chen, Efren Delos Santos, Osvaldo Dos Santos, Matthew Bursavich, Adam M Gilbert, John W Ellingboe, Semiramis Ayral-Kaloustian, Gulnaz Khafizova, Natasja Brooijmans, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Jay Gibbons, Robert Abraham, Tarek S Mansour.
Abstract
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19954970 DOI： 10.1016/j.bmcl.2009.11.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823