Literature DB >> 1995489

Inhibition of respiration of tumor cells by methylglyoxal and protection of inhibition by lactaldehyde.

M Ray1, J Halder, S K Dutta, S Ray.   

Abstract

The effect of methylglyoxal (MG), ascorbic acid and lactaldehyde has been tested on the in vitro respiration of Ehrlich ascites carcinoma (EAC) cells and several normal and malignant human tissues. Methylglyoxal inhibited the respiration of each type of malignant cell and tissue tested, but it had practically no inhibitory effect on the respiration of any of the normal cells and tissues. Ascorbic acid exhibited a synergistic effect with MG in inhibiting the respiration of all the neoplastic cells. In the presence of lactaldehyde, a catabolite of MG, the inhibitory effect of MG on the respiration of tumor cells was significantly reduced. Lactaldehyde can exert a similar protective effect on the loss of viability and transplantability of MG-treated EAC cells.

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Year:  1991        PMID： 1995489     DOI： 10.1002/ijc.2910470421

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  12 in total

1.  Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.

Authors:  Soumya SinhaRoy; Sambhunath Banerjee; Manju Ray; Subhankar Ray
Journal:  Mol Cell Biochem       Date:  2005-03       Impact factor: 3.396

2.  Similar nature of inhibition of mitochondrial respiration of heart tissue and malignant cells by methylglyoxal. A vital clue to understand the biochemical basis of malignancy.

Authors:  S Ray; S Biswas; M Ray
Journal:  Mol Cell Biochem       Date:  1997-06       Impact factor: 3.396

3.  Reduction of methylglyoxal in Escherichia coli K12 by an aldehyde reductase and alcohol dehydrogenase.

Authors:  K Misra; A B Banerjee; S Ray; M Ray
Journal:  Mol Cell Biochem       Date:  1996-03-23       Impact factor: 3.396

4.  Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal.

Authors:  S Biswas; M Ray; S Misra; D P Dutta; S Ray
Journal:  Biochem J       Date:  1997-04-15       Impact factor: 3.857

5.  Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal.

Authors:  M Ray; N Basu; S Ray
Journal:  Mol Cell Biochem       Date:  1997-12       Impact factor: 3.396

6.  Interaction of aldehydes with glyoxalase I and the status of several aldehyde metabolizing enzymes of Ehrlich ascites carcinoma cells.

Authors:  S Biswas; S Bhattacharjee; M Ray; S Ray
Journal:  Mol Cell Biochem       Date:  1996-12-06       Impact factor: 3.396

7.  Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression.

Authors:  Tiantian He; Huaibin Zhou; Chunmei Li; Yuan Chen; Xiaowan Chen; Chenli Li; Jiating Mao; Jianxin Lyu; Qing H Meng
Journal:  Cancer Biol Ther       Date:  2016-07-25       Impact factor: 4.742

8.  Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal.

Authors:  S Ray; S Dutta; J Halder; M Ray
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

9.  Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect.

Authors:  Aparajita Pal; Dipa Talukdar; Anirban Roy; Subhankar Ray; Asish Mallick; Chitra Mandal; Manju Ray
Journal:  Int J Nanomedicine       Date:  2015-05-12

10.  Antioxidant-rich leaf extract of Barringtonia racemosa significantly alters the in vitro expression of genes encoding enzymes that are involved in methylglyoxal degradation III.

Authors:  Kin Weng Kong; Azlina Abdul Aziz; Nurhanani Razali; Norhaniza Aminuddin; Sarni Mat Junit
Journal:  PeerJ       Date:  2016-08-25       Impact factor: 2.984
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