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Literature DB >> 1995479

Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine.

N K Berdinskikh¹, N A Ignatenko, S P Zaletok, K P Ganina, V A Chorniy.

Abstract

Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.

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Year: 1991 PMID： 1995479 DOI： 10.1002/ijc.2910470404

Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396

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Cited

8 in total

Review 1. Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.

Authors: W Raasch; U Schäfer; J Chun; P Dominiak
Journal: Br J Pharmacol Date: 2001-07 Impact factor: 8.739

2. Pharmacological characteristics of the specific transporter for the endogenous cell growth inhibitor agmatine in six tumor cell lines.

Authors: A Heinen; M Brüss; H Bönisch; M Göthert; G J Molderings
Journal: Int J Colorectal Dis Date: 2003-02-20 Impact factor: 2.571

8. Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: association with increased cell proliferation and elevated ornithine decarboxylase activity.

Authors: N Takada; M Kitano; T Chen; Y Yano; S Otani; S Fukushima
Journal: Jpn J Cancer Res Date: 1994-11

8 in total

Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine.

Review 1. Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.

2. Pharmacological characteristics of the specific transporter for the endogenous cell growth inhibitor agmatine in six tumor cell lines.

3. Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.

4. Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions.

5. Study on changes of polyamine levels in mice with the development of U14 cervical cancer.

6. Metabolic models predict bacterial passengers in colorectal cancer.

7. Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder.

8. Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: association with increased cell proliferation and elevated ornithine decarboxylase activity.