Sung Kim1, Michael Eleff, Nicos Nicolaou. 1. Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, New Jersey, USA. kim18@umdnj.edu
Abstract
BACKGROUND: Head and neck cutaneous squamous cell carcinoma (SCC) metastatic to lymph nodes is commonly treated with surgery plus radiotherapy. METHODS: We present the case of a 92-year-old man with cutaneous SCC metastatic to the neck (7 cm) who was treated with primary cetuximab and has had a durable complete response for 7 months. Because of his age, comorbidities, and unresectable neck lymphadenopathy, he received primary cetuximab. He received a 400 mg/m(2) loading dose and a 250 mg/m(2) weekly dose for 3 months and then had to discontinue as a result of other unrelated medical issues. RESULTS: The patient had a complete response by 6 weeks. Seven months after discontinuing cetuximab, he continues to have a complete response. CONCLUSIONS: Primary cetuximab for cutaneous SCC metastatic to lymph nodes is an area that bears further investigation because of its apparent efficacy and excellent toxicity profile.
BACKGROUND: Head and neck cutaneous squamous cell carcinoma (SCC) metastatic to lymph nodes is commonly treated with surgery plus radiotherapy. METHODS: We present the case of a 92-year-old man with cutaneous SCC metastatic to the neck (7 cm) who was treated with primary cetuximab and has had a durable complete response for 7 months. Because of his age, comorbidities, and unresectable neck lymphadenopathy, he received primary cetuximab. He received a 400 mg/m(2) loading dose and a 250 mg/m(2) weekly dose for 3 months and then had to discontinue as a result of other unrelated medical issues. RESULTS: The patient had a complete response by 6 weeks. Seven months after discontinuing cetuximab, he continues to have a complete response. CONCLUSIONS: Primary cetuximab for cutaneous SCC metastatic to lymph nodes is an area that bears further investigation because of its apparent efficacy and excellent toxicity profile.
Authors: Giuseppina Della Vittoria Scarpati; Francesco Perri; Salvatore Pisconti; Giuseppe Costa; Filippo Ricciardiello; Salvatore Del Prete; Alberto Napolitano; Marco Carraturo; Salvatore Mazzone; Raffaele Addeo Journal: Mol Clin Oncol Date: 2016-01-27
Authors: Nichole R Dean; Larissa Sweeny; J Scott Magnuson; William R Carroll; Daniel Robinson; Renee A Desmond; Eben L Rosenthal Journal: J Skin Cancer Date: 2011-06-09