Literature DB >> 1995298

Production of platelet-like particles by a human megakaryoblastic leukemia cell line (MEG-01).

K Takeuchi1, M Ogura, H Saito, M Satoh, M Takeuchi.   

Abstract

The distribution of microtubules and platelet-specific glycoproteins (GPIIb/IIIa) in particles was probed by an immunofluorescence method using anti-tubulin and anti-GPIIb/IIIa antibodies to identify whether particles released from a human megakaryoblastic cell line (MEG-01) are platelets. The fluorescence image showing anti-tubulin staining of the particles revealed a characteristic ring structure observed in platelets. Anti-platelet GPIIb/IIIa antibody staining showed an image in which small patches or spots were seen throughout the particle with brighter staining at the periphery. No significant difference was observed between these particles and human blood platelets under immunofluorescent staining. These results show that MEG-01 cells released platelet-like particles.

Entities:  

Mesh：

Year:  1991        PMID： 1995298     DOI： 10.1016/0014-4827(91)90560-h

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  12 in total

1.  The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.

Authors:  Julie Sahler; Jamie J Bernard; Sherry L Spinelli; Neil Blumberg; Richard P Phipps
Journal:  Thromb Res       Date:  2011-01-26       Impact factor: 3.944

2.  Platelets and platelet-like particles mediate intercellular RNA transfer.

Authors:  Antonina Risitano; Lea M Beaulieu; Olga Vitseva; Jane E Freedman
Journal:  Blood       Date:  2012-05-17       Impact factor: 22.113

3.  Slowed decay of mRNAs enhances platelet specific translation.

Authors:  Eric W Mills; Rachel Green; Nicholas T Ingolia
Journal:  Blood       Date:  2017-02-17       Impact factor: 22.113

4.  Genetic engineering of platelets to neutralize circulating tumor cells.

Authors:  Jiahe Li; Charles C Sharkey; Brittany Wun; Jane L Liesveld; Michael R King
Journal:  J Control Release       Date:  2016-02-26       Impact factor: 9.776

Review 5.  Recent developments in ex vivo platelet production.

Authors:  Retno Wahyu Nurhayati; Yoshihiro Ojima; Masahito Taya
Journal:  Cytotechnology       Date:  2016-03-22       Impact factor: 2.058

6.  Characterization of a novel transcript of prostaglandin endoperoxide H synthase 1 with a tissue-specific profile of expression.

Authors:  M H Plant; O Laneuville
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

7.  High-Throughput Production of Platelet-Like Particles.

Authors:  Kylie M Persson; Pauline V Kneller; Mark W Livingston; Lucas M Bush; Tara L Deans
Journal:  Methods Mol Biol       Date:  2021

8.  A novel method for overexpression of peroxisome proliferator-activated receptor-γ in megakaryocyte and platelet microparticles achieves transcellular signaling.

Authors:  J Sahler; C Woeller; S Spinelli; N Blumberg; R Phipps
Journal:  J Thromb Haemost       Date:  2012-12       Impact factor: 5.824

9.  15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.

Authors:  Jamie J O'Brien; Sherry L Spinelli; Joanna Tober; Neil Blumberg; Charles W Francis; Mark B Taubman; James Palis; Kathryn E Seweryniak; Jacqueline M Gertz; Richard P Phipps
Journal:  Blood       Date:  2008-08-28       Impact factor: 22.113

10.  Leukaemia/lymphoma cell microparticles in childhood mature B cell neoplasms.

Authors:  S Savaşan; M Büyükavci; S Buck; Y Ravindranath
Journal:  J Clin Pathol       Date:  2004-06       Impact factor: 3.411
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