| Literature DB >> 19952542 |
Carey Farquhar1, Dorothy Mbori-Ngacha, Julie Overbaugh, Dalton Wamalwa, Jennifer Harris, Rose Bosire, Grace John-Stewart.
Abstract
HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2-5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.Entities:
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Year: 2010 PMID: 19952542 PMCID: PMC2788745 DOI: 10.1097/QAD.0b013e32832326d8
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.177