| Literature DB >> 19952430 |
Kazunori Sano1, Emi Koushi, Keiichi Irie, Sei Higuchi, Ryota Tsuchihashi, Junei Kinjo, Nobuaki Egashira, Ryozo Oishi, Naoki Uchida, Hiroshi Nagai, Ryoji Nishimura, Hiroyuki Tanaka, Satoshi Morimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara.
Abstract
The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression.Entities:
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Year: 2009 PMID： 19952430 DOI： 10.1248/bpb.32.2065
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233