Literature DB >> 19952353

The macrophage: the intersection between HIV infection and atherosclerosis.

Suzanne M Crowe1, Clare L V Westhorpe, Nigora Mukhamedova, Anthony Jaworowski, Dmitri Sviridov, Michael Bukrinsky.   

Abstract

HIV-infected individuals are at increased risk of coronary artery disease (CAD) with underlying mechanisms including chronic immune activation and inflammation secondary to HIV-induced microbial translocation and low-grade endotoxemia; direct effects of HIV and viral proteins on macrophage cholesterol metabolism; and dyslipidemia related to HIV infection and specific antiretroviral therapies. Monocytes are the precursors of the lipid-laden foam cells within the atherosclerotic plaque and produce high levels of proinflammatory cytokines such as IL-6. The minor CD14+/CD16+ "proinflammatory" monocyte subpopulation is preferentially susceptible to HIV infection and may play a critical role in the pathogenesis of HIV-related CAD. In this review, the central role of monocytes/macrophages in HIV-related CAD and the importance of inflammation and cholesterol metabolism are discussed.

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Year:  2009        PMID： 19952353      PMCID： PMC3085483          DOI： 10.1189/jlb.0809580

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  156 in total

1.  Kinetics of plasma cytokines and chemokines during primary HIV-1 infection and after analytical treatment interruption.

Authors:  B Barqasho; P Nowak; A Tjernlund; S Kinloch; L-E Goh; F Lampe; M Fisher; J Andersson; A Sönnerborg
Journal:  HIV Med       Date:  2009-02       Impact factor: 3.180

2.  Genetically elevated C-reactive protein and vascular disease.

Authors:  Roger M Harbord; Debbie A Lawlor; George Davey Smith
Journal:  N Engl J Med       Date:  2009-02-26       Impact factor: 91.245

Review 3.  TLRs and innate immunity.

Authors:  Bruce A Beutler
Journal:  Blood       Date:  2008-08-29       Impact factor: 22.113

4.  Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype.

Authors:  Joseph J Boyle; Heather A Harrington; Emma Piper; Kay Elderfield; Jaroslav Stark; Robert C Landis; Dorian O Haskard
Journal:  Am J Pathol       Date:  2009-03       Impact factor: 4.307

Review 5.  The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease.

Authors:  Simon W Rabkin
Journal:  Nat Clin Pract Cardiovasc Med       Date:  2009-03

Review 6.  Mechanisms and consequences of macrophage apoptosis in atherosclerosis.

Authors:  Tracie Seimon; Ira Tabas
Journal:  J Lipid Res       Date:  2008-10-25       Impact factor: 5.922

7.  Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy.

Authors:  Allison C Ross; Rachel Armentrout; Mary Ann O'Riordan; Norma Storer; Nesrine Rizk; Danielle Harrill; Dalia El Bejjani; Grace A McComsey
Journal:  J Acquir Immune Defic Syndr       Date:  2008-12-15       Impact factor: 3.731

Review 8.  Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL.

Authors:  Michael S Brown; Joseph L Goldstein
Journal:  J Lipid Res       Date:  2008-10-29       Impact factor: 5.922

9.  Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients.

Authors:  Emmanouil Papasavvas; Maxwell Pistilli; Griffin Reynolds; Robert Bucki; Livio Azzoni; Jihed Chehimi; Paul A Janmey; Mark J DiNubile; Joe Ondercin; Jay R Kostman; Karam C Mounzer; Luis J Montaner
Journal:  AIDS       Date:  2009-01-28       Impact factor: 4.177

Review 10.  Immune and inflammatory mechanisms of atherosclerosis (*).

Authors:  Elena Galkina; Klaus Ley
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527
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  66 in total

1.  Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection.

Authors:  Emily S Ford; Jamieson H Greenwald; Aaron G Richterman; Adam Rupert; Lauren Dutcher; Yunden Badralmaa; Ven Natarajan; Catherine Rehm; Colleen Hadigan; Irini Sereti
Journal:  AIDS       Date:  2010-06-19       Impact factor: 4.177

2.  Analysis of ABCA1 and Cholesterol Efflux in HIV-Infected Cells.

Authors:  Nigora Mukhamedova; Beda Brichacek; Christina Darwish; Anastas Popratiloff; Dmitri Sviridov; Michael Bukrinsky
Journal:  Methods Mol Biol       Date:  2016

3.  MicroRNA biomarkers associated with type 1 myocardial infarction in HIV-positive individuals.

Authors:  Neal Yuan; Rebecca Scherzer; Kahraman Tanriverdi; Jeffrey Martin; Smruti Rahalkar; Priscilla Hsue
Journal:  AIDS       Date:  2019-12-01       Impact factor: 4.177

Review 4.  Inflammatory co-morbidities in HIV+ individuals: learning lessons from healthy ageing.

Authors:  Anna C Hearps; Genevieve E Martin; Reena Rajasuriar; Suzanne M Crowe
Journal:  Curr HIV/AIDS Rep       Date:  2014-03       Impact factor: 5.071

5.  Elevated numbers of CD163+ macrophages in hearts of simian immunodeficiency virus-infected monkeys correlate with cardiac pathology and fibrosis.

Authors:  Joshua A Walker; Megan L Sulciner; Katherine D Nowicki; Andrew D Miller; Tricia H Burdo; Kenneth C Williams
Journal:  AIDS Res Hum Retroviruses       Date:  2014-03-11       Impact factor: 2.205

6.  Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation.

Authors:  Salma S Syed; Rula S Balluz; Edmond K Kabagambe; William A Meyer; Susan Lukas; Craig M Wilson; Bill G Kapogiannis; Sharon A Nachman; John W Sleasman
Journal:  AIDS Res Hum Retroviruses       Date:  2012-12-03       Impact factor: 2.205

7.  Biomarkers of microbial translocation and macrophage activation: association with progression of subclinical atherosclerosis in HIV-1 infection.

Authors:  Theodoros Kelesidis; Michelle A Kendall; Otto O Yang; Howard N Hodis; Judith S Currier
Journal:  J Infect Dis       Date:  2012-10-12       Impact factor: 5.226

8.  HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.

Authors:  Susanna L Lamers; Rebecca Rose; Ekaterina Maidji; Melissa Agsalda-Garcia; David J Nolan; Gary B Fogel; Marco Salemi; Debra L Garcia; Paige Bracci; William Yong; Deborah Commins; Jonathan Said; Negar Khanlou; Charles H Hinkin; Miguel Valdes Sueiras; Glenn Mathisen; Suzanne Donovan; Bruce Shiramizu; Cheryl A Stoddart; Michael S McGrath; Elyse J Singer
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

Review 9.  Immune activation and cardiovascular disease in chronic HIV infection.

Authors:  Chris T Longenecker; Claire Sullivan; Jason V Baker
Journal:  Curr Opin HIV AIDS       Date:  2016-03       Impact factor: 4.283

Review 10.  HIV-1 Nef in macrophage-mediated disease pathogenesis.

Authors:  Susanna L Lamers; Gary B Fogel; Elyse J Singer; Marco Salemi; David J Nolan; Leanne C Huysentruyt; Michael S McGrath
Journal:  Int Rev Immunol       Date:  2012-12       Impact factor: 5.311
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