BACKGROUND/AIMS: Hepatic mitochondrial beta-oxidation is considered to play a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine whether there were differences between patients with NASH and healthy controls in a breath test with 13C-octanoate, a medium-chain fatty acid. METHODOLOGY: The subjects were 8 patients (5 men, 3 women, median age 46.5 years) with histologically proven NASH and 6 healthy controls (5 men, 1 women, and median age 27.8 years). The 13C breath test was performed for 4 hours using the BreathID system with a 100 mL of water containing 100 mg 13C-octanoate. RESULTS: There were no significant differences between NASH patients and controls about all breath test parameters. CONCLUSIONS: NASH-mediated changes in breath test parameters after ingestion of 13C-octanoate were not observed in our study. The present study findings suggest the possible preservation of 13C-octanoate metabolism (mitochondrial beta-oxidation) in patients with NASH.
BACKGROUND/AIMS: Hepatic mitochondrial beta-oxidation is considered to play a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine whether there were differences between patients with NASH and healthy controls in a breath test with 13C-octanoate, a medium-chain fatty acid. METHODOLOGY: The subjects were 8 patients (5 men, 3 women, median age 46.5 years) with histologically proven NASH and 6 healthy controls (5 men, 1 women, and median age 27.8 years). The 13C breath test was performed for 4 hours using the BreathID system with a 100 mL of water containing 100 mg 13C-octanoate. RESULTS: There were no significant differences between NASH patients and controls about all breath test parameters. CONCLUSIONS: NASH-mediated changes in breath test parameters after ingestion of 13C-octanoate were not observed in our study. The present study findings suggest the possible preservation of 13C-octanoate metabolism (mitochondrial beta-oxidation) in patients with NASH.
Authors: Jeffrey D Browning; Jonathan A Baker; Thomas Rogers; Jeannie Davis; Santhosh Satapati; Shawn C Burgess Journal: Am J Clin Nutr Date: 2011-03-02 Impact factor: 7.045
Authors: Jutta Keller; Heinz F Hammer; Paul R Afolabi; Marc Benninga; Osvaldo Borrelli; Enrique Dominguez-Munoz; Dan Dumitrascu; Oliver Goetze; Stephan L Haas; Bruno Hauser; Daniel Pohl; Silvia Salvatore; Marc Sonyi; Nikhil Thapar; Kristin Verbeke; Mark R Fox Journal: United European Gastroenterol J Date: 2021-06-14 Impact factor: 4.623
Authors: Irini Manoli; Alexandra R Pass; Elizabeth A Harrington; Jennifer L Sloan; Jack Gagné; Samantha McCoy; Sarah L Bell; Jacob D Hattenbach; Brooks P Leitner; Courtney J Duckworth; Laura A Fletcher; Thomas M Cassimatis; Carolina I Galarreta; Audrey Thurm; Joseph Snow; Carol Van Ryzin; Susan Ferry; Nicholas Ah Mew; Oleg A Shchelochkov; Kong Y Chen; Charles P Venditti Journal: Genet Med Date: 2021-04-05 Impact factor: 8.822