Literature DB >> 19950021

Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.

Sakae Tanaka1, Hidetoshi Wakeyama, Toru Akiyama, Katsuhiko Takahashi, Hitoshi Amano, Keiichi I Nakayama, Kozo Nakamura.   

Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

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Year:  2010        PMID： 19950021     DOI： 10.1007/978-1-4419-1050-9_12

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  7 in total

1.  Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation.

Authors:  Shijun Hu; Mei Huang; Patricia K Nguyen; Yongquan Gong; Zongjin Li; Fangjun Jia; Feng Lan; Junwei Liu; Divya Nag; Robert C Robbins; Joseph C Wu
Journal:  Circulation       Date:  2011-09-13       Impact factor: 29.690

Review 2.  Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts.

Authors:  Brendan F Boyce
Journal:  J Bone Miner Res       Date:  2013-04       Impact factor: 6.741

3.  Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis.

Authors:  Suo-Fu Ye; Yong Yang; Lin Wu; Wei-Wei Ma; Hui-Hui Zeng
Journal:  J Zhejiang Univ Sci B       Date:  2017-05       Impact factor: 3.066

Review 4.  Advances in the regulation of osteoclasts and osteoclast functions.

Authors:  B F Boyce
Journal:  J Dent Res       Date:  2013-08-01       Impact factor: 6.116

5.  Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NF‑κB signaling pathway.

Authors:  Yu Chen; Bangguo Wei; Panpan Xu; Huadong Tang; Langlang Yang; Yuhang Wang; Yingxiao Fu; Xiaodi Yang; Yingji Mao
Journal:  Mol Med Rep       Date:  2021-02-12       Impact factor: 2.952

6.  Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1-Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis.

Authors:  Ke Fang; Yuki Murakami; Seiji Kanda; Takaki Shimono; Anh Tuan Dang; Mitsuaki Ono; Toshimasa Nishiyama
Journal:  Int J Mol Sci       Date:  2022-07-15       Impact factor: 6.208

7.  Calcitonin inhibits SDCP-induced osteoclast apoptosis and increases its efficacy in a rat model of osteoporosis.

Authors:  Yi-Jie Kuo; Fon-Yih Tsuang; Jui-Sheng Sun; Chi-Hung Lin; Chia-Hsien Chen; Jia-Ying Li; Yi-Chian Huang; Wei-Yu Chen; Chin-Bin Yeh; Jia-Fwu Shyu
Journal:  PLoS One       Date:  2012-07-06       Impact factor: 3.240
  7 in total

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