| Literature DB >> 19950011 |
Keith Thompson1, Anke J Roelofs, Marjo Jauhiainen, Hannu Mönkkönen, Jukka Mönkkönen, Michael J Rogers.
Abstract
After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.Entities:
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Year: 2010 PMID： 19950011 DOI： 10.1007/978-1-4419-1050-9_2
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622