OBJECTIVE: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. MATERIAL AND METHODS: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. RESULTS AND CONCLUSION: The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
OBJECTIVE: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. MATERIAL AND METHODS: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6-174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6-6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. RESULTS AND CONCLUSION: The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
Authors: Y Ishihara; T Nishihara; T Kuroyanagi; N Shirozu; E Yamagishi; M Ohguchi; M Koide; N Ueda; K Amano; T Noguchi Journal: J Periodontal Res Date: 1997-08 Impact factor: 4.419
Authors: Luigi Nibali; Gareth S Griffiths; Nikos Donos; Mohamed Parkar; Francesco D'Aiuto; Maurizio S Tonetti; Peter M Brett Journal: J Clin Periodontol Date: 2008-03 Impact factor: 8.728
Authors: L Nibali; G Pelekos; F D'Aiuto; N Chaudhary; R Habeeb; D Ready; M Parkar; N Donos Journal: Clin Oral Investig Date: 2012-08-24 Impact factor: 3.573
Authors: Francisco Mesa; Francisco O'Valle; Manfredi Rizzo; Francesco Cappello; Nikos Donos; Mohamed Parkar; Navidah Chaudhary; Francesco Carini; Ricardo Muñoz; Luigi Nibali Journal: PLoS One Date: 2014-02-13 Impact factor: 3.240