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Literature DB >> 19946756

Mitochondrial cholesterol transporter, StAR, inhibits human THP-1 monocyte-derived macrophage apoptosis.

Qianming Bai¹, Xiaobo Li, Yanxia Ning, Fengdi Zhao, Lianhua Yin.

Abstract

Steroidogenic acute regulatory protein (StAR) plays an important role in the maintenance of intracellular lipid homeostasis. Macrophages are the key cellular player in the pathophysiology of atherosclerosis. Imbalance of macrophage lipid homeostasis causes cellular apoptosis, which is the key process in the initiation of atherosclerosis. The present study has investigated the effects of StAR in the apoptotic process of human THP-1 derived macrophages induced by serum withdrawal or Ox-LDL. Overexpression of StAR significantly decreased the number of apoptotic macrophages by decreasing the expression of pro-apoptotic genes Caspase-3 and Bax mRNA and protein levels, as well as through increasing expression of anti-apoptotic gene Bcl-2 mRNA and protein levels in the absence and presence of Ox-LDL. The results indicate that StAR plays an important role in macrophage and foam cell apoptotic processing, which may provide a potential method for preventing atherosclerosis.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19946756 DOI： 10.1007/s11745-009-3375-6

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

41 in total

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Authors: Yongjie Ma; Leyuan Xu; Daniel Rodriguez-Agudo; Xiaobo Li; Douglas M Heuman; Phillip B Hylemon; William M Pandak; Shunlin Ren
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10. Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.

Authors: William M Pandak; Shunlin Ren; Dalila Marques; Elizabeth Hall; Kaye Redford; Darrell Mallonee; Patricia Bohdan; Douglas Heuman; Gregorio Gil; Phillip Hylemon
Journal: J Biol Chem Date: 2002-10-03 Impact factor: 5.157

7 in total

Mitochondrial cholesterol transporter, StAR, inhibits human THP-1 monocyte-derived macrophage apoptosis.

Review 1. Monocyte recruitment and foam cell formation in atherosclerosis.

Review 2. Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system.

Review 3. Molecular biology of steroid hormone synthesis.

4. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.

5. Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

6. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms.

7. Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax.

8. Preserved antioxidative defense of lipoproteins in renal failure and during hemodialysis.

9. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

10. Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.

1. Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.

Review 2. Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses.

3. Cortisol Metabolism in Carp Macrophages: A Role for Macrophage-Derived Cortisol in M1/M2 Polarization.

4. Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate.

Review 5. Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Review 6. An intracrine view of sex steroids, immunity, and metabolic regulation.

Review 7. Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis.