Literature DB >> 19946728

Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata.

Agnès Thierry1, Bernard Dujon, Guy-Franck Richard.   

Abstract

Megasatellites are DNA tandem arrays made of large motifs; they were discovered in the yeast Candida glabrata. They are widespread in this species (40 copies) but are not found in any other hemiascomycete so far, raising the intriguing question of their origin. They are found mainly in genes encoding cell wall products, suggesting that megasatellites were selected for a function linked to cell-cell adhesion or to pathogenicity. Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed.

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Year:  2009        PMID： 19946728     DOI： 10.1007/s00018-009-0216-y

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  29 in total

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Review 2.  Mechanisms of common fragile site instability.

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Authors:  Kevin J Verstrepen; An Jansen; Fran Lewitter; Gerald R Fink
Journal:  Nat Genet       Date:  2005-08-07       Impact factor: 38.330

Review 5.  Fragile sites and human disease.

Authors:  Kim Debacker; R Frank Kooy
Journal:  Hum Mol Genet       Date:  2007-06-13       Impact factor: 6.150

6.  Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1,6 glucan-cross-linked cell wall protein.

Authors:  Matthew B Frieman; J Michael McCaffery; Brendan P Cormack
Journal:  Mol Microbiol       Date:  2002-10       Impact factor: 3.501

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8.  Replication stress induces tumor-like microdeletions in FHIT/FRA3B.

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9.  Genomic polymorphism in the population of Candida glabrata: gene copy-number variation and chromosomal translocations.

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Journal:  Fungal Genet Biol       Date:  2008-12-06       Impact factor: 3.495

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  17 in total

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Review 2.  Adhesins in human fungal pathogens: glue with plenty of stick.

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Journal:  Eukaryot Cell       Date:  2013-02-08

3.  Detection and characterization of megasatellites in orthologous and nonorthologous genes of 21 fungal genomes.

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Journal:  Eukaryot Cell       Date:  2013-03-29

4.  Dynamic evolution of megasatellites in yeasts.

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Journal:  Nucleic Acids Res       Date:  2010-03-31       Impact factor: 16.971

5.  Candida glabrata Pwp7p and Aed1p are required for adherence to human endothelial cells.

Authors:  Chirayu Desai; John Mavrianos; Neeraj Chauhan
Journal:  FEMS Yeast Res       Date:  2011-07-29       Impact factor: 2.796

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Journal:  FEMS Microbiol Lett       Date:  2010-09-16       Impact factor: 2.742

7.  Functional variability in adhesion and flocculation of yeast megasatellite genes.

Authors:  Cyril Saguez; David Viterbo; Stéphane Descorps-Declère; Brendan P Cormack; Bernard Dujon; Guy-Franck Richard
Journal:  Genetics       Date:  2022-05-05       Impact factor: 4.402

8.  Genome-wide replication landscape of Candida glabrata.

Authors:  Stéphane Descorps-Declère; Cyril Saguez; Axel Cournac; Martial Marbouty; Thomas Rolland; Laurence Ma; Christiane Bouchier; Ivan Moszer; Bernard Dujon; Romain Koszul; Guy-Franck Richard
Journal:  BMC Biol       Date:  2015-09-02       Impact factor: 7.431

9.  Deep conservation of human protein tandem repeats within the eukaryotes.

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Journal:  Mol Biol Evol       Date:  2014-02-03       Impact factor: 16.240

10.  Balanced gene losses, duplications and intensive rearrangements led to an unusual regularly sized genome in Arbutus unedo chloroplasts.

Authors:  Fernando Martínez-Alberola; Eva M Del Campo; David Lázaro-Gimeno; Sergio Mezquita-Claramonte; Arantxa Molins; Isabel Mateu-Andrés; Joan Pedrola-Monfort; Leonardo M Casano; Eva Barreno
Journal:  PLoS One       Date:  2013-11-18       Impact factor: 3.240
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