Literature DB >> 19946541

False positive diagnosis of malignancy in a case of cryptogenic organising pneumonia presenting as a pulmonary mass with mediastinal nodes detected on fluorodeoxyglucose-positron emission tomography: a case report.

Aravind Ponnuswamy1, Neeraj Mediratta, Iain D Lyburn, James P Finnerty.   

Abstract

INTRODUCTION: We report the case of a patient with positive findings on a lung emission tomography/computed tomography (PET/CT) scan, with possible contra lateral mediastinal involvement, which strongly suggested an inoperable lung carcinoma. The lung mass proved to be a cryptogenic organising pneumonia. While the latter has previously been shown to be PET/CT positive, mediastinal involvement simulating malignant spread has not been previously reported. CASE
PRESENTATION: A 50-year-old Caucasian woman presented with a history of unproductive cough and was found to have a mass in the right upper lobe as shown on chest X-ray and a computed tomography scan. A subsequent PET/CT scan showed strong uptake in the right upper lobe (maximum standard uptake values (SUVmax) 9.6) with increased uptake in the adjacent mediastinum and contralateral mediastinal nodes. Surgical resection and mediastinoscopy revealed cryptogenic organising pneumonia, with enlarged reactive mediastinal lymph nodes.
CONCLUSION: The case illustrates the limits of PET/CT scanning as a diagnostic tool, and emphasizes the importance of obtaining histological confirmation of malignant diseases whenever possible.

Entities:  

Year:  2009        PMID: 19946541      PMCID: PMC2783064          DOI: 10.1186/1752-1947-3-124

Source DB:  PubMed          Journal:  J Med Case Rep        ISSN: 1752-1947


  6 in total

Review 1.  Organising pneumonia.

Authors:  J F Cordier
Journal:  Thorax       Date:  2000-04       Impact factor: 9.139

2.  Hypermetabolism on F-18 FDG PET of multiple pulmonary nodules resulting from bronchiolitis obliterans organizing pneumonia.

Authors:  Lewis Shin; Douglas S Katz; Elizabeth Yung
Journal:  Clin Nucl Med       Date:  2004-10       Impact factor: 7.794

3.  Factors associated with false-positive staging of lung cancer by positron emission tomography.

Authors:  P F Roberts; D M Follette; D von Haag; J A Park; P E Valk; T R Pounds; D M Hopkins
Journal:  Ann Thorac Surg       Date:  2000-10       Impact factor: 4.330

4.  Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition).

Authors:  Gerard A Silvestri; Michael K Gould; Mitchell L Margolis; Lynn T Tanoue; Douglas McCrory; Eric Toloza; Frank Detterbeck
Journal:  Chest       Date:  2007-09       Impact factor: 9.410

5.  Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection.

Authors:  Robert J Downey; Timothy Akhurst; Mithat Gonen; Alain Vincent; Manjit S Bains; Steven Larson; Valerie Rusch
Journal:  J Clin Oncol       Date:  2004-08-15       Impact factor: 44.544

6.  Idiopathic interstitial pneumonias: prevalence of mediastinal lymph node enlargement in 206 patients.

Authors:  Carolina Althoff Souza; Nestor L Müller; Kyung Soo Lee; Takeshi Johkoh; Hiromitsu Mitsuhiro; Semin Chong
Journal:  AJR Am J Roentgenol       Date:  2006-04       Impact factor: 3.959

  6 in total
  4 in total

1.  Organizing Pneumonia as a Histopathological Term.

Authors:  Fatma Tokgöz Akyıl; Meltem Ağca; Aysun Mısırlıoğlu; Ayşe Alp Arsev; Mustafa Akyıl; Tülin Sevim
Journal:  Turk Thorac J       Date:  2017-07-01

Review 2.  Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature.

Authors:  Shuanshuan Xie; Changxing Shen; Yunfeng Zhang; Kun Lu; Feng Hu; Min Tan; Haiyan Lin; Lei Xu; Qing Yuan; Xiaolian Song; Changhui Wang
Journal:  Int J Clin Exp Pathol       Date:  2014-12-01

3.  The Evaluation of FDG PET/CT Scan Findings in Patients with Organizing Pneumonia Mimicking Lung Cancer.

Authors:  Yurdanur Erdoğan; Berna Akıncı Özyürek; Özlem Özmen; Nilgün Yılmaz Demirci; Sezgi Şahin Duyar; Yeliz Dadalı; Funda Demirağ; Jale Karakaya
Journal:  Mol Imaging Radionucl Ther       Date:  2015-06-05

4.  An unusual presentation of a more common disease entity.

Authors:  Charlotte Van de Kerkhove; Walter De Wever; Eric K Verbeken; Christophe Deroose; Kris Nackaerts
Journal:  Breathe (Sheff)       Date:  2018-03
  4 in total

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