BACKGROUND: We assessed the influence of atorvastatin on selected indicators of an inflammation, function of the left ventricle and factors affecting the occurrence of rehospitalisation and mortality in patients with dilated cardiomyopathy (DCM). MATERIAL/ METHODS: In a prospective, randomized study, 68 patients with DCM with LVEF <or=40% were divided into 2 groups: group A consisted of 41 patients who were administeredatorvastatin 40 mg/daily for 2 months and 10 mg for the next 4 months; and B consisted of 27 patients who were treated without statin therapy. Initial tests included the measurement of TNF-alpha, IL-6, IL-10, and NT-proBNP concentrations, echocardiographic examination and the assessment of exercise capacity in the 6-min walk test (6-MWT). RESULTS: In group A (vs group B), IL-6 was significantly lower (p<0.0001) after 2 months of treatment with atorvastatin. IL-6and TNFalpha decreased significantly in group A, compared with initial values (p=0.0017 and p=0.0087, respectively). NT-proBNP was also significantly reduced in the atorvastatin group (p=0.0004), while in the control group an increase of NT-proBNP was observed (p=0.0021). After 6 months, the number of patients in NYHA class III was significantly decreased (from 47% to 22.5%) in group A, and the distance in 6-MWT considerably lengthened (p<0.05), while in group B the distance shortened significantly (p=0.0147). After 6 months, patients without statin treatment required more hospitalizations because of cardiac insufficiency (32% vs 12%, p=0.04). CONCLUSIONS:Atorvastatin treatment significantly decreases the concentration of IL-6, and NT-proBNP in patients with DCM after 2 months of therapy. These results were consistent with the significant lengthening of the distance in 6-MWT, improvement of NYHA class, and fewer rehospitalizations due to heart failure, observed both after 2 and 6 months of atorvastatin treatment (ClinialTrial.gov No.: NCT01015144).
RCT Entities:
BACKGROUND: We assessed the influence of atorvastatin on selected indicators of an inflammation, function of the left ventricle and factors affecting the occurrence of rehospitalisation and mortality in patients with dilated cardiomyopathy (DCM). MATERIAL/ METHODS: In a prospective, randomized study, 68 patients with DCM with LVEF <or=40% were divided into 2 groups: group A consisted of 41 patients who were administered atorvastatin 40 mg/daily for 2 months and 10 mg for the next 4 months; and B consisted of 27 patients who were treated without statin therapy. Initial tests included the measurement of TNF-alpha, IL-6, IL-10, and NT-proBNP concentrations, echocardiographic examination and the assessment of exercise capacity in the 6-min walk test (6-MWT). RESULTS: In group A (vs group B), IL-6 was significantly lower (p<0.0001) after 2 months of treatment with atorvastatin. IL-6 and TNFalpha decreased significantly in group A, compared with initial values (p=0.0017 and p=0.0087, respectively). NT-proBNP was also significantly reduced in the atorvastatin group (p=0.0004), while in the control group an increase of NT-proBNP was observed (p=0.0021). After 6 months, the number of patients in NYHA class III was significantly decreased (from 47% to 22.5%) in group A, and the distance in 6-MWT considerably lengthened (p<0.05), while in group B the distance shortened significantly (p=0.0147). After 6 months, patients without statin treatment required more hospitalizations because of cardiac insufficiency (32% vs 12%, p=0.04). CONCLUSIONS:Atorvastatin treatment significantly decreases the concentration of IL-6, and NT-proBNP in patients with DCM after 2 months of therapy. These results were consistent with the significant lengthening of the distance in 6-MWT, improvement of NYHA class, and fewer rehospitalizations due to heart failure, observed both after 2 and 6 months of atorvastatin treatment (ClinialTrial.gov No.: NCT01015144).
Authors: Theodore M Brasky; John D Potter; Alan R Kristal; Ruth E Patterson; Ulrike Peters; Maryam M Asgari; Mark D Thornquist; Emily White Journal: Cancer Causes Control Date: 2012-01-03 Impact factor: 2.506
Authors: Sahera Dirajlal-Fargo; Bruce Kinley; Ying Jiang; Chris T Longenecker; Corrilynn O Hileman; Sara Debanne; Grace A McComsey Journal: AIDS Date: 2015-01-28 Impact factor: 4.177
Authors: Agata Bielecka-Dabrowa; Jan Henryk Goch; Jacek Rysz; Marek Maciejewski; Ravi Desai; Wilbert S Aronow; Maciej Banach Journal: Lipids Health Dis Date: 2010-02-23 Impact factor: 3.876
Authors: Lauren N Strand; Rebekah L Young; Alain G Bertoni; David A Bluemke; Gregory L Burke; Joao A Lima; Nona Sotoodehnia; Bruce M Psaty; Robyn L McClelland; Susan R Heckbert; Joseph A Delaney Journal: Pharmacoepidemiol Drug Saf Date: 2018-01-30 Impact factor: 2.890
Authors: Theodore M Brasky; Jingmin Liu; Emily White; Ulrike Peters; John D Potter; Roland B Walter; Christina S Baik; Dorothy S Lane; JoAnn E Manson; Mara Z Vitolins; Matthew A Allison; Jean Y Tang; Jean Wactawski-Wende Journal: Int J Cancer Date: 2014-03-20 Impact factor: 7.396
Authors: Agata Bielecka-Dabrowa; Dimitri P Mikhailidis; Manfredi Rizzo; Stephan von Haehling; Jacek Rysz; Maciej Banach Journal: Lipids Health Dis Date: 2013-04-08 Impact factor: 3.876