| Literature DB >> 19945875 |
Paul A Barsanti1, Weibo Wang, Zhi-Jie Ni, David Duhl, Nathan Brammeier, Eric Martin, Dirksen Bussiere, Annette O Walter.
Abstract
A series of tetrahydro-beta-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19945875 DOI： 10.1016/j.bmcl.2009.11.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823