Literature DB >> 19945782

Short hairpin RNA-mediated inhibition of S100A4 promotes apoptosis and suppresses proliferation of BGC823 gastric cancer cells in vitro and in vivo.

Jun Hua1, Danqi Chen, Hao Fu, Ruixiu Zhang, Wei Shen, Shanshan Liu, Kailai Sun, Xiuju Sun.   

Abstract

S100A4 has been found to be over-expressed in gastric cancer and associated with poor prognosis of the patients, yet the exact role and molecular mechanism of S100A4 in gastric cancer has not been determined. We found that S100A4 inhibition by RNAi lead to reduced proliferation and increased apoptosis of gastric cancer cell line BGC823. Intratumoral injection of pS100A4-shRNA suppressed tumor growth in nude mice. We also found that S100A4 inhibition decreased the expression of both NF-kappaB p65 and phospho(Ser32)-I-kappaB-alpha. Our results suggested that S100A4 may be an attractive candidate for the therapeutic targeting of gastric cancer. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19945782     DOI： 10.1016/j.canlet.2009.11.007

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells.

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Journal:  World J Gastroenterol       Date:  2012-03-07       Impact factor: 5.742

Review 2.  Delivery of intracellular-acting biologics in pro-apoptotic therapies.

Authors:  Hongmei Li; Chris E Nelson; Brian C Evans; Craig L Duvall
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

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Journal:  Visc Med       Date:  2017-02-09

Review 4.  The role of the basal stem cell of the human breast in normal development and cancer.

Authors:  Jose Russo; Irma H Russo
Journal:  Adv Exp Med Biol       Date:  2011       Impact factor: 2.622

Review 5.  S100 proteins in cancer.

Authors:  Anne R Bresnick; David J Weber; Danna B Zimmer
Journal:  Nat Rev Cancer       Date:  2015-02       Impact factor: 60.716

6.  Deregulated miR-296/S100A4 axis promotes tumor invasion by inducing epithelial-mesenchymal transition in human ovarian cancer.

Authors:  Wang Yan; Jiaqi Chen; Zhaoying Chen; Huimin Chen
Journal:  Am J Cancer Res       Date:  2016-01-15       Impact factor: 6.166

7.  Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.

Authors:  Mathias Dahlmann; Ulrike Sack; Pia Herrmann; Margit Lemm; Iduna Fichtner; Peter M Schlag; Ulrike Stein
Journal:  Oncotarget       Date:  2012-08

8.  S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.

Authors:  Ulrike Sack; Wolfgang Walther; Dominic Scudiero; Mike Selby; Jutta Aumann; Clara Lemos; Iduna Fichtner; Peter M Schlag; Robert H Shoemaker; Ulrike Stein
Journal:  Mol Biol Cell       Date:  2011-07-27       Impact factor: 4.138

9.  Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth.

Authors:  Takahiro Ochiya; Keizo Takenaga; Hideya Endo
Journal:  Angiogenesis       Date:  2013-08-09       Impact factor: 9.596

10.  miR-3189-3p Mimics Enhance the Effects of S100A4 siRNA on the Inhibition of Proliferation and Migration of Gastric Cancer Cells by Targeting CFL2.

Authors:  Yue Bian; Junfu Guo; Linlin Qiao; Xiuju Sun
Journal:  Int J Mol Sci       Date:  2018-01-13       Impact factor: 5.923
  10 in total

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