AIM: We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice. MAIN METHODS: We performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules. KEY FINDINGS: Immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2-6. We observed clear co-localization between Notch-1 and myogenin (4.9+/-1.3%) in the hypertrophied muscle at 4days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1+/-1.2%). SIGNIFICANCE: Notch-1 may play an important role in the maintenance of quiescent satellite cells.
AIM: We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice. MAIN METHODS: We performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules. KEY FINDINGS: Immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2-6. We observed clear co-localization between Notch-1 and myogenin (4.9+/-1.3%) in the hypertrophied muscle at 4days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1+/-1.2%). SIGNIFICANCE: Notch-1 may play an important role in the maintenance of quiescent satellite cells.
Authors: Jonah D Lee; Christopher S Fry; Jyothi Mula; Tyler J Kirby; Janna R Jackson; Fujun Liu; Lin Yang; Esther E Dupont-Versteegden; John J McCarthy; Charlotte A Peterson Journal: J Gerontol A Biol Sci Med Sci Date: 2015-04-15 Impact factor: 6.053
Authors: John J McCarthy; Jyothi Mula; Mitsunori Miyazaki; Rod Erfani; Kelcye Garrison; Amreen B Farooqui; Ratchakrit Srikuea; Benjamin A Lawson; Barry Grimes; Charles Keller; Gary Van Zant; Kenneth S Campbell; Karyn A Esser; Esther E Dupont-Versteegden; Charlotte A Peterson Journal: Development Date: 2011-09 Impact factor: 6.868
Authors: Daniel W D West; Leslie M Baehr; George R Marcotte; Courtney M Chason; Luis Tolento; Aldrin V Gomes; Sue C Bodine; Keith Baar Journal: J Physiol Date: 2015-12-15 Impact factor: 5.182