| Literature DB >> 19945436 |
Chun-Yu Chen1, Ning-Sheng Lai, Jaw-Ji Yang, Hsien-Lu Huang, Wei-Chuan Hung, Chin Li, Ta-Hsien Lin, Hsien-Bin Huang.
Abstract
In this report, we identified the novel protein heart protein phosphatase 1-binding protein (Hepp1), encoded by FLJ23654. Hepp1 associated with protein phosphatase 1 (PP1) by yeast two-hybrid, GST pull-down, co-immunoprecipitation, and far Western blotting assays. Northern blot analysis revealed that Hepp1 mRNA was only expressed in human heart and testis. Recombinant Hepp1 slightly enhanced the enzymatic activity of PP1 and antagonized the ability of phospho-inhibitor-1 or inhibitor-2 to inhibit PP1. Hepp1 protein in human heart tissues was detected by Western blot analysis. Together, our data suggest that Hepp1 can play a role in cardiac functions by working in concert with PP1. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19945436 DOI： 10.1016/j.bbrc.2009.11.123
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575