Literature DB >> 19945058

Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.

Stephen B Liggett1.   

Abstract

The major pathologic beta(1)-adrenergic receptor (beta(1)-AR) subtype in heart failure is beta(1)-AR. The authors' laboratory has thus pursued genetic variation of the beta(1)-AR gene at the molecular, cellular, physiologic, and clinical levels as the potential basis for interindividual variability in the response to beta-blocker treatment during heart failure. This article reviews these findings, with emphasis on mechanism of action and future directions.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 19945058      PMCID： PMC2825120          DOI： 10.1016/j.hfc.2009.08.011

Source DB:  PubMed          Journal:  Heart Fail Clin        ISSN： 1551-7136            Impact factor:   3.179


  15 in total

1.  A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.

Authors:  Eric J Eichhorn; Michael J Domanski; Heidi Krause-Steinrauf; Michael R Bristow; Philip W Lavori
Journal:  N Engl J Med       Date:  2001-05-31       Impact factor: 91.245

2.  Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.

Authors:  Kersten M Small; Jeanne Mialet-Perez; Carrie A Seman; Cheryl T Theiss; Kari M Brown; Stephen B Liggett
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-19       Impact factor: 11.205

3.  Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.

Authors:  Amy J Sehnert; Susan E Daniels; Michael Elashoff; James A Wingrove; Christopher R Burrow; Benjamin Horne; Joseph B Muhlestein; Mark Donahue; Stephen B Liggett; Jeffrey L Anderson; William E Kraus
Journal:  J Am Coll Cardiol       Date:  2008-06-23       Impact factor: 24.094

4.  A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors.

Authors:  K M Small; S L Forbes; F F Rahman; K M Bridges; S B Liggett
Journal:  J Biol Chem       Date:  2000-07-28       Impact factor: 5.157

5.  A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.

Authors:  D A Mason; J D Moore; S A Green; S B Liggett
Journal:  J Biol Chem       Date:  1999-04-30       Impact factor: 5.157

6.  Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.

Authors:  Kersten M Small; Lynne E Wagoner; Albert M Levin; Sharon L R Kardia; Stephen B Liggett
Journal:  N Engl J Med       Date:  2002-10-10       Impact factor: 91.245

7.  A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

Authors:  Stephen B Liggett; Jeanne Mialet-Perez; Surai Thaneemit-Chen; Stewart A Weber; Scott M Greene; Danielle Hodne; Bradley Nelson; Jennifer Morrison; Michael J Domanski; Lynne E Wagoner; William T Abraham; Jeffrey L Anderson; John F Carlquist; Heidi J Krause-Steinrauf; Laura C Lazzeroni; J David Port; Philip W Lavori; Michael R Bristow
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-14       Impact factor: 11.205

8.  Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs.

Authors:  Steven M Swift; Brigitte R Gaume; Kersten M Small; Bruce J Aronow; Stephen B Liggett
Journal:  Physiol Genomics       Date:  2008-07-29       Impact factor: 3.107

9.  Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.

Authors:  Kersten M Small; Jeanne Mialet-Perez; Stephen B Liggett
Journal:  J Cardiovasc Pharmacol       Date:  2008-01       Impact factor: 3.105

10.  A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.

Authors:  Stephen B Liggett; Sharon Cresci; Reagan J Kelly; Faisal M Syed; Scot J Matkovich; Harvey S Hahn; Abhinav Diwan; Jeffrey S Martini; Li Sparks; Rohan R Parekh; John A Spertus; Walter J Koch; Sharon L R Kardia; Gerald W Dorn
Journal:  Nat Med       Date:  2008-04-20       Impact factor: 53.440
View more
  5 in total

1.  Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.

Authors:  Anush Oganesian; Vladimir Yarov-Yarovoy; William C Parks; Debra A Schwinn
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-16       Impact factor: 11.205

Review 2.  Pathological ventricular remodeling: mechanisms: part 1 of 2.

Authors:  Jana S Burchfield; Min Xie; Joseph A Hill
Journal:  Circulation       Date:  2013-07-23       Impact factor: 29.690

3.  β1 adrenergic receptor polymorphisms and heart failure: a meta-analysis on susceptibility, response to β-blocker therapy and prognosis.

Authors:  Wen-Nan Liu; Kai-Li Fu; Hai-Yang Gao; Yuan-Yuan Shang; Zhi-Hao Wang; Gui-Hua Jiang; Yun Zhang; Wei Zhang; Ming Zhong
Journal:  PLoS One       Date:  2012-07-17       Impact factor: 3.240

4.  β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes.

Authors:  Misun Park; Gopireddy R Reddy; Gerd Wallukat; Yang K Xiang; Susan F Steinberg
Journal:  Sci Rep       Date:  2017-08-11       Impact factor: 4.379

Review 5.  Sex/Gender- and Age-Related Differences in β-Adrenergic Receptor Signaling in Cardiovascular Diseases.

Authors:  Daniela Liccardo; Beatrice Arosio; Graziamaria Corbi; Alessandro Cannavo
Journal:  J Clin Med       Date:  2022-07-22       Impact factor: 4.964
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.