INTRODUCTION: Surgical treatment of breast cancer in very young patients (<35 years) is still a matter of debate, since age is a predictive factor of local recurrence after breast conservation. PATIENTS AND METHODS: We retrospectively evaluated outcome and prognostic factors of 201 consecutive patients treated with breast conservation followed by whole breast irradiation between 1997 and 2004 with special attention paid to local control. The average follow up was 72 months (range 13-133 months). RESULTS: The mean age was 32 years (Range 20-34). Invasive ductal carcinoma was found in 175 (87.1%) patients. Two (1%) patients had invasive lobular carcinoma. One-hundred and eighteen patients (58.7%) had tumors of 2 cm or smaller. Sentinel lymph node biopsy was performed in 105 (52.2%) patients. One-hundred and ten (54.7%) patients had node-negative disease, 68 (33.8%) patients had 1-3 positive nodes and 23 (11.4%) +4 positive nodes. Eighteen patients (9.0%) developed a local recurrence, 25 (12.5%) developed distant metastases and 23 patients (11.4%) died during follow up. The 5- and 10-year cumulative incidence of local events were 8.2% and 12,3% respectively. The univariate analysis did not identify any variables affecting local disease-free survival. CONCLUSIONS: Breast conservation in very young patients achieves an acceptable local control rate. No prognostic factors were associated with local events. Copyright (c) 2009. Published by Elsevier Ltd.
INTRODUCTION: Surgical treatment of breast cancer in very young patients (<35 years) is still a matter of debate, since age is a predictive factor of local recurrence after breast conservation. PATIENTS AND METHODS: We retrospectively evaluated outcome and prognostic factors of 201 consecutive patients treated with breast conservation followed by whole breast irradiation between 1997 and 2004 with special attention paid to local control. The average follow up was 72 months (range 13-133 months). RESULTS: The mean age was 32 years (Range 20-34). Invasive ductal carcinoma was found in 175 (87.1%) patients. Two (1%) patients had invasive lobular carcinoma. One-hundred and eighteen patients (58.7%) had tumors of 2 cm or smaller. Sentinel lymph node biopsy was performed in 105 (52.2%) patients. One-hundred and ten (54.7%) patients had node-negative disease, 68 (33.8%) patients had 1-3 positive nodes and 23 (11.4%) +4 positive nodes. Eighteen patients (9.0%) developed a local recurrence, 25 (12.5%) developed distant metastases and 23 patients (11.4%) died during follow up. The 5- and 10-year cumulative incidence of local events were 8.2% and 12,3% respectively. The univariate analysis did not identify any variables affecting local disease-free survival. CONCLUSIONS: Breast conservation in very young patients achieves an acceptable local control rate. No prognostic factors were associated with local events. Copyright (c) 2009. Published by Elsevier Ltd.
Authors: E P Bastos; H Brentani; C A B Pereira; A Polpo; L Lima; R D Puga; F S Pasini; C A B T Osorio; R A Roela; M I Achatz; A P Trapé; A M Gonzalez-Angulo; M M Brentani Journal: PLoS One Date: 2016-05-06 Impact factor: 3.240
Authors: Dirce Maria Carraro; Maria Aparecida Azevedo Koike Folgueira; Bianca Cristina Garcia Lisboa; Eloisa Helena Ribeiro Olivieri; Ana Cristina Vitorino Krepischi; Alex Fiorini de Carvalho; Louise Danielle de Carvalho Mota; Renato David Puga; Maria do Socorro Maciel; Rodrigo Augusto Depieri Michelli; Eduardo Carneiro de Lyra; Stana Helena Giorgi Grosso; Fernando Augusto Soares; Maria Isabel Alves de Souza Waddington Achatz; Helena Brentani; Carlos Alberto Moreira-Filho; Maria Mitzi Brentani Journal: PLoS One Date: 2013-03-01 Impact factor: 3.240
Authors: Darren R Brenner; Nigel T Brockton; Joanne Kotsopoulos; Michelle Cotterchio; Beatrice A Boucher; Kerry S Courneya; Julia A Knight; Ivo A Olivotto; May Lynn Quan; Christine M Friedenreich Journal: Cancer Causes Control Date: 2016-03-12 Impact factor: 2.506