BACKGROUND: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. METHODS: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. RESULTS: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m(2), 95% confidence interval (CI)=1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value-mean)/standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. CONCLUSIONS: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications.
BACKGROUND:Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. METHODS: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. RESULTS: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m(2), 95% confidence interval (CI)=1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value-mean)/standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. CONCLUSIONS: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications.
Authors: Bulent Gorenek; Antonio Pelliccia; Emelia J Benjamin; Giuseppe Boriani; Harry J Crijns; Richard I Fogel; Isabelle C Van Gelder; Martin Halle; Gulmira Kudaiberdieva; Deirdre A Lane; Torben Bjerregaard Larsen; Gregory Y H Lip; Maja-Lisa Løchen; Francisco Marin; Josef Niebauer; Prashanthan Sanders; Lale Tokgozoglu; Marc A Vos; David R Van Wagoner; Laurent Fauchier; Irina Savelieva; Andreas Goette; Stefan Agewall; Chern-En Chiang; Márcio Figueiredo; Martin Stiles; Timm Dickfeld; Kristen Patton; Massimo Piepoli; Ugo Corra; Pedro Manuel Marques-Vidal; Pompilio Faggiano; Jean-Paul Schmid; Ana Abreu Journal: Eur J Prev Cardiol Date: 2016-11-04 Impact factor: 7.804
Authors: Bulent Gorenek; Antonio Pelliccia; Emelia J Benjamin; Giuseppe Boriani; Harry J Crijns; Richard I Fogel; Isabelle C Van Gelder; Martin Halle; Gulmira Kudaiberdieva; Deirdre A Lane; Torben Bjerregaard Larsen; Gregory Y H Lip; Maja-Lisa Løchen; Francisco Marín; Josef Niebauer; Prashanthan Sanders; Lale Tokgozoglu; Marc A Vos; David R Van Wagoner; Laurent Fauchier; Irina Savelieva; Andreas Goette; Stefan Agewall; Chern-En Chiang; Márcio Figueiredo; Martin Stiles; Timm Dickfeld; Kristen Patton; Massimo Piepoli; Ugo Corra; Pedro Manuel Marques-Vidal; Pompilio Faggiano; Jean-Paul Schmid; Ana Abreu Journal: Europace Date: 2017-02-01 Impact factor: 5.214
Authors: Michael A Rosenberg; Kristen K Patton; Nona Sotoodehnia; Maria G Karas; Jorge R Kizer; Peter J Zimetbaum; James D Chang; David Siscovick; John S Gottdiener; Richard A Kronmal; Susan R Heckbert; Kenneth J Mukamal Journal: Eur Heart J Date: 2012-09-12 Impact factor: 29.983
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Authors: Michael A Rosenberg; Robert C Kaplan; David S Siscovick; Bruce M Psaty; Susan R Heckbert; Christopher Newton-Cheh; Kenneth J Mukamal Journal: Am J Epidemiol Date: 2014-06-18 Impact factor: 4.897
Authors: Jens Cosedis Nielsen; Yenn-Jiang Lin; Marcio Jansen de Oliveira Figueiredo; Alireza Sepehri Shamloo; Alberto Alfie; Serge Boveda; Nikolaos Dagres; Dario Di Toro; Lee L Eckhardt; Kenneth Ellenbogen; Carina Hardy; Takanori Ikeda; Aparna Jaswal; Elizabeth Kaufman; Andrew Krahn; Kengo Kusano; Valentina Kutyifa; Han S Lim; Gregory Y H Lip; Santiago Nava-Townsend; Hui-Nam Pak; Gerardo Rodríguez Diez; William Sauer; Anil Saxena; Jesper Hastrup Svendsen; Diego Vanegas; Marmar Vaseghi; Arthur Wilde; T Jared Bunch; Alfred E Buxton; Gonzalo Calvimontes; Tze-Fan Chao; Lars Eckardt; Heidi Estner; Anne M Gillis; Rodrigo Isa; Josef Kautzner; Philippe Maury; Joshua D Moss; Gi-Byung Nam; Brian Olshansky; Luis Fernando Pava Molano; Mauricio Pimentel; Mukund Prabhu; Wendy S Tzou; Philipp Sommer; Janice Swampillai; Alejandro Vidal; Thomas Deneke; Gerhard Hindricks; Christophe Leclercq Journal: Europace Date: 2020-08-01 Impact factor: 5.214