Mikko P Pakarinen1, Antti I Koivusalo, Risto J Rintala. 1. Section of Pediatric Surgery, Hospital for Children and Adolescents, University of Helsinki, Box 281, FIN-00029 HUS Helsinki, Finland. mikko.pakarinen@hus.fi
Abstract
BACKGROUND: We investigated whether mortality, intestinal adaptation, and liver function differ between intestinal failure (IF) patients with either short bowel (SB) or bowel dysmotility (DM). PATIENTS AND METHODS: Twenty-six consecutive patients with SB (n = 20) or DM (n = 6) treated between 2000 and 2007 were retrospectively assessed. Intestinal failure was defined as less than 25% of age-adjusted small intestinal length or dependence on parenteral nutrition (PN) more than 6 months. RESULTS: Median age-adjusted small intestinal length (17% vs 45%) and gestational age (35 vs 40 weeks) were (P < .05) shorter, whereas proportion of the remaining colon (86% vs 0%) was (P < .05) higher in the SB group relative to the DM group. Overall survival was 92%. Median peak serum bilirubin (80 vs 25 micromol/L) and rate of cholestasis (11/20 vs 0/6) were higher (P < .05) in the SB group. Short bowel rather than DM as an etiology of IF predicted weaning off PN (RR, 39.3; 95% confidence interval [CI], 1.43-526; P < .01) and development of cholestasis (risk ration [RR], 18.3; 95% CI, 0.658-127; P < .05). Three SB children developed liver failure and two died, whereas neither of these occurred in the DM group. CONCLUSIONS: Children with SB are more likely to wean off PN but more prone to cholestatic liver disease than those with DM as an etiology of IF.
BACKGROUND: We investigated whether mortality, intestinal adaptation, and liver function differ between intestinal failure (IF) patients with either short bowel (SB) or bowel dysmotility (DM). PATIENTS AND METHODS: Twenty-six consecutive patients with SB (n = 20) or DM (n = 6) treated between 2000 and 2007 were retrospectively assessed. Intestinal failure was defined as less than 25% of age-adjusted small intestinal length or dependence on parenteral nutrition (PN) more than 6 months. RESULTS: Median age-adjusted small intestinal length (17% vs 45%) and gestational age (35 vs 40 weeks) were (P < .05) shorter, whereas proportion of the remaining colon (86% vs 0%) was (P < .05) higher in the SB group relative to the DM group. Overall survival was 92%. Median peak serum bilirubin (80 vs 25 micromol/L) and rate of cholestasis (11/20 vs 0/6) were higher (P < .05) in the SB group. Short bowel rather than DM as an etiology of IF predicted weaning off PN (RR, 39.3; 95% confidence interval [CI], 1.43-526; P < .01) and development of cholestasis (risk ration [RR], 18.3; 95% CI, 0.658-127; P < .05). Three SBchildren developed liver failure and two died, whereas neither of these occurred in the DM group. CONCLUSIONS:Children with SB are more likely to wean off PN but more prone to cholestatic liver disease than those with DM as an etiology of IF.
Authors: Robert H Squires; Jane Balint; Simon Horslen; Paul W Wales; Jason Soden; Christopher Duggan; Ruosha Li; Steven H Belle Journal: J Pediatr Gastroenterol Nutr Date: 2014-10 Impact factor: 2.839