Carlos Robles-Jara1, Carlos Robles-Medranda. 1. Gastroenterology Division, Instituto Ecuatoriano de Enfermedades Digestivas y Pelvicas (IECED), Portoviejo, Manabi, Ecuador. carlosroblesj@hotmail.com
Abstract
INTRODUCTION: It has been reported that a local injection of 5-fluorouracil (5-FU) administered endoscopically can have a favorable result in patients with early gastric cancer. METHODS: We report the application of a local injection of 5-FU administered endoscopically in three patients with advanced gastric cancer (AGC) who refused or were not suitable for surgery or systemic chemotherapy. The benefits of locally applied endoscopic chemotherapy (EC) with 5-FU as an alternative therapy were evaluated. RESULTS: Good tolerance with an important reduction of the tumor size and no adverse reactions was observed in all three patients. CONCLUSION: EC with 5-FU is a feasible technique that can be applied in a certain group of patients with AGC. Further studies will be required to corroborate these results.
INTRODUCTION: It has been reported that a local injection of 5-fluorouracil (5-FU) administered endoscopically can have a favorable result in patients with early gastric cancer. METHODS: We report the application of a local injection of 5-FU administered endoscopically in three patients with advanced gastric cancer (AGC) who refused or were not suitable for surgery or systemic chemotherapy. The benefits of locally applied endoscopic chemotherapy (EC) with 5-FU as an alternative therapy were evaluated. RESULTS: Good tolerance with an important reduction of the tumor size and no adverse reactions was observed in all three patients. CONCLUSION: EC with 5-FU is a feasible technique that can be applied in a certain group of patients with AGC. Further studies will be required to corroborate these results.
Authors: T Ohyama; J Yamasaki; T Imanishi; M Ohgaki; H Tsujimoto; M Shirasu; M Shimotsuma; A Hagiwara; K Sawai; T Takahashi Journal: Gan To Kagaku Ryoho Date: 1995-09