OBJECTIVE AND METHODS: To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. RESULTS: HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric and texture variables were useful in the discrimination of the different types of follicular lesions. Among these variables, r(2), a parameter related to the granularity of the nucleus presented the best accuracy, sensitivity, specificity and positive and negative predictive values, distinguishing benign from malignant lesions. CONCLUSION: The morphometric analysis of nuclear chromatin images may add accuracy to the differential diagnosis of follicular patterned lesions.
OBJECTIVE AND METHODS: To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. RESULTS: HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric and texture variables were useful in the discrimination of the different types of follicular lesions. Among these variables, r(2), a parameter related to the granularity of the nucleus presented the best accuracy, sensitivity, specificity and positive and negative predictive values, distinguishing benign from malignant lesions. CONCLUSION: The morphometric analysis of nuclear chromatin images may add accuracy to the differential diagnosis of follicular patterned lesions.
Authors: R C Ferreira; L L Cunha; P S Matos; R L Adam; F Soares; J Vassallo; L S Ward Journal: Cell Oncol (Dordr) Date: 2012-12-05 Impact factor: 6.730
Authors: Anna M Brown; Sidhartha Nagala; Mary A McLean; Yonggang Lu; Daniel Scoffings; Aditya Apte; Mithat Gonen; Hilda E Stambuk; Ashok R Shaha; R Michael Tuttle; Joseph O Deasy; Andrew N Priest; Piyush Jani; Amita Shukla-Dave; John Griffiths Journal: Magn Reson Med Date: 2015-05-20 Impact factor: 4.668