BACKGROUND & OBJECTIVES: Contrast media may cause contrast-induced nephropathy (CIN) in risk group. This study was taken up to establish possible effects of non ionic low osmolar contrast medium administration on oxidant/antioxidant status and nitric oxide (NO) levels in rat kidney tissues. METHODS: Fourteen female, 14 wk old Wistar-albino rats were divided into 2 groups of 7 rats each (control and contrast groups). Non ionic low osmolar contrast medium was administered iv to the animals in the contrast group. The day after, animals were sacrificed and malondialdehyde (MDA) and NO levels and activities of antioxidant [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] and oxidant [xanthine oxidase (XO)] enzymes were measured in kidney tissues. Serum creatinine levels were measured to evaluate kidney functions. RESULTS: Contrast medium administration caused an increase in MDA levels and a decrease in NO levels in kidney tissues. INTERPRETATION & CONCLUSIONS: The results suggest that non ionic low osmolar contrast medium administration leads to accelerated oxidant reactions and decreased NO level in rat kidney tissues. Further studies need to be done to assess the role of these changes in CIN.
BACKGROUND & OBJECTIVES: Contrast media may cause contrast-induced nephropathy (CIN) in risk group. This study was taken up to establish possible effects of non ionic low osmolar contrast medium administration on oxidant/antioxidant status and nitric oxide (NO) levels in rat kidney tissues. METHODS: Fourteen female, 14 wk old Wistar-albino rats were divided into 2 groups of 7 rats each (control and contrast groups). Non ionic low osmolar contrast medium was administered iv to the animals in the contrast group. The day after, animals were sacrificed and malondialdehyde (MDA) and NO levels and activities of antioxidant [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] and oxidant [xanthine oxidase (XO)] enzymes were measured in kidney tissues. Serum creatinine levels were measured to evaluate kidney functions. RESULTS: Contrast medium administration caused an increase in MDA levels and a decrease in NO levels in kidney tissues. INTERPRETATION & CONCLUSIONS: The results suggest that non ionic low osmolar contrast medium administration leads to accelerated oxidant reactions and decreased NO level in rat kidney tissues. Further studies need to be done to assess the role of these changes in CIN.
Authors: Cuneyt Tayman; Alparslan Tonbul; Aydın Kosus; Ibrahim Murat Hirfanoglu; Hacer Haltas; Sema Uysal; Mustafa Mansur Tatli; Fatih Andiran Journal: Pediatr Surg Int Date: 2011-06-28 Impact factor: 1.827
Authors: Mustafa Yılmaz; Alp Aydınalp; Kaan Okyay; Abdullah Tekin; Uğur Abbas Bal; Nilüfer Bayraktar; Aylin Yıldırır; Haldun Müderrisoğlu Journal: Cardiorenal Med Date: 2015-05-30 Impact factor: 2.041
Authors: Anne-Marie Beirne; Oliver Mitchelmore; Susana Palma; Mervyn Andiapen; Krishnaraj S Rathod; Victoria Hammond; Anna Bellin; Jackie Cooper; Paul Wright; Sotiris Antoniou; Muhammad Magdi Yaqoob; Huseyin Naci; Anthony Mathur; Amrita Ahluwalia; Daniel A Jones Journal: J Cardiovasc Pharmacol Ther Date: 2021-03-25 Impact factor: 2.457