| Literature DB >> 19942440 |
Hiroko Tani1, Keiko Hasumi, Tomoki Tatefuji, Ken Hashimoto, Hiroyuki Koshino, Shunya Takahashi.
Abstract
The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors. Crown Copyright (c) 2009. Published by Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19942440 DOI： 10.1016/j.bmc.2009.11.007
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641