OBJECTIVE: To investigate the influence of the recombinant human endostatin and gemcitabine combined with HIFU on the mouse xenograft model of pancreatic cancer. METHODS: Use human pancreatic cancer cell line PANC-1 to set up the mouse xenograft model, then randomized into four arms. Each arm was treated with gemcitabine, endostatin, gemcitabine combined with endostatin and normal saline respectively. Observe the volume of the tumor, the serum VEGF level and MVD in the tumor tissue among the different arms. All mice were treated with HIFU, then pathological examination was done. RESULTS: The tumor volume, serum VEGF level and MVD in the combined-therapy arm are all lower than the monotherapy arms and the control arm. The coagulation necrosis occurred in tumors after HIFU treatment. CONCLUSION: Endostatin and gemcitabine has better effect than gemcitabine or endostatin monotherapy on the animal xenograft model of human pancreatic cancer. HIFU combined with chemotherapy and/or targeted therapy may enhance the effect for pancreatic cancer. 2009 Elsevier Masson SAS. All rights reserved.
OBJECTIVE: To investigate the influence of the recombinant humanendostatin and gemcitabine combined with HIFU on the mouse xenograft model of pancreatic cancer. METHODS: Use humanpancreatic cancer cell line PANC-1 to set up the mouse xenograft model, then randomized into four arms. Each arm was treated with gemcitabine, endostatin, gemcitabine combined with endostatin and normal saline respectively. Observe the volume of the tumor, the serum VEGF level and MVD in the tumor tissue among the different arms. All mice were treated with HIFU, then pathological examination was done. RESULTS: The tumor volume, serum VEGF level and MVD in the combined-therapy arm are all lower than the monotherapy arms and the control arm. The coagulation necrosis occurred in tumors after HIFU treatment. CONCLUSION:Endostatin and gemcitabine has better effect than gemcitabine or endostatin monotherapy on the animal xenograft model of humanpancreatic cancer. HIFU combined with chemotherapy and/or targeted therapy may enhance the effect for pancreatic cancer. 2009 Elsevier Masson SAS. All rights reserved.
Authors: Jae Young Lee; Byung Ihn Choi; Ji Kon Ryu; Yong-Tae Kim; Joo Ha Hwang; Se Hyung Kim; Joon Koo Han Journal: Korean J Radiol Date: 2011-03-03 Impact factor: 3.500
Authors: Won Chang; Jae Young Lee; Jae Hwan Lee; Jae Seok Bae; Yeon Jin Cho; Kook Jin Kang; Keonho Son; Yul Ri Chung; Kyoung Bun Lee; Joon Koo Han Journal: Ultrasonography Date: 2017-10-13