A M Gilbert1, T M Olino, P Houck, A Fagiolini, D J Kupfer, E Frank. 1. Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States. agilbert2@nshs.edu
Abstract
BACKGROUND: Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder. METHODS: 154 bipolar I disorder patients were followed for 15-43months at the Bipolar Disorders Center for Pennsylvanians. Using a multinomial logistic regression we examined predictors of employment group including self-reported cognitive problems, mood symptoms, education and age. Cognitive functioning was measured via 4 self-report items assessing memory/concentration at baseline and termination. Employment status was recorded at baseline and termination. Employment was categorized as working (full-time, part-time, homemaker, volunteer) or not working (leave of absence, disability, unemployed, no longer volunteering) at each time point. Patients were categorized as good stable, improving, worsening and poor stable. RESULTS: Baseline self-reported concentration problems and years of education significantly predicted employment trajectory. LIMITATIONS: Post-hoc analyses of existing clinical data. CONCLUSIONS: Self-reported concentration problems assessed in the context of specific areas of functioning may serve as a sensitive predictor of functional outcome in patients diagnosed with bipolar I disorder. Copyright 2009 Elsevier B.V. All rights reserved.
BACKGROUND:Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder. METHODS: 154 bipolar I disorderpatients were followed for 15-43months at the Bipolar Disorders Center for Pennsylvanians. Using a multinomial logistic regression we examined predictors of employment group including self-reported cognitive problems, mood symptoms, education and age. Cognitive functioning was measured via 4 self-report items assessing memory/concentration at baseline and termination. Employment status was recorded at baseline and termination. Employment was categorized as working (full-time, part-time, homemaker, volunteer) or not working (leave of absence, disability, unemployed, no longer volunteering) at each time point. Patients were categorized as good stable, improving, worsening and poor stable. RESULTS: Baseline self-reported concentration problems and years of education significantly predicted employment trajectory. LIMITATIONS: Post-hoc analyses of existing clinical data. CONCLUSIONS: Self-reported concentration problems assessed in the context of specific areas of functioning may serve as a sensitive predictor of functional outcome in patients diagnosed with bipolar I disorder. Copyright 2009 Elsevier B.V. All rights reserved.
Authors: M Tohen; J Hennen; C M Zarate; R J Baldessarini; S M Strakowski; A L Stoll; G L Faedda; T Suppes; P Gebre-Medhin; B M Cohen Journal: Am J Psychiatry Date: 2000-02 Impact factor: 18.112
Authors: Lewis L Judd; Hagop S Akiskal; Pamela J Schettler; Jean Endicott; Jack Maser; David A Solomon; Andrew C Leon; John A Rice; Martin B Keller Journal: Arch Gen Psychiatry Date: 2002-06
Authors: A Martínez-Arán; E Vieta; F Colom; C Torrent; J Sánchez-Moreno; M Reinares; A Benabarre; J M Goikolea; E Brugué; C Daban; M Salamero Journal: Bipolar Disord Date: 2004-06 Impact factor: 6.744
Authors: Robert M Post; Kirk D Denicoff; Gabriele S Leverich; Lori L Altshuler; Mark A Frye; Trisha M Suppes; A John Rush; Paul E Keck; Susan L McElroy; David A Luckenbaugh; Chad Pollio; Ralph Kupka; Willem A Nolen Journal: J Clin Psychiatry Date: 2003-06 Impact factor: 4.384
Authors: Faith B Dickerson; John J Boronow; Cassie R Stallings; Andrea E Origoni; Sara Cole; Robert H Yolken Journal: Psychiatr Serv Date: 2004-01 Impact factor: 3.084
Authors: Inger Burnett-Zeigler; Mark A Ilgen; Kipling Bohnert; Erin Miller; Khairul Islam; Kara Zivin Journal: Community Ment Health J Date: 2012-03-27
Authors: Juul Koene; Susan Zyto; Jaap van der Stel; Natasja van Lang; Marion Ammeraal; Ralph W Kupka; Jaap van Weeghel Journal: Int J Bipolar Disord Date: 2022-03-14
Authors: Young Sup Woo; Joshua D Rosenblat; Ron Kakar; Won-Myong Bahk; Roger S McIntyre Journal: Clin Psychopharmacol Neurosci Date: 2016-02-29 Impact factor: 2.582