OBJECTIVE: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. METHODS: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of > or = 90 cm in men and > or = 80 cm in women for the values of > or = 85 cm and > or = 90 cm, respectively, in the modified Japanese criteria and for > 102 cm and > 88cm, respectively, in the modified NCEP criteria. RESULTS: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95% CI, 1.25-5.18; P=0.01) and 3.94 (95% CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. CONCLUSION: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of > or = 90 cm in men and > or = 80 cm in women is a better predictor of each ischemic stroke subtype in the Japanese population. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population. METHODS: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of > or = 90 cm in men and > or = 80 cm in women for the values of > or = 85 cm and > or = 90 cm, respectively, in the modified Japanese criteria and for > 102 cm and > 88cm, respectively, in the modified NCEP criteria. RESULTS: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P=0.02), 2.55 (95% CI, 1.25-5.18; P=0.01) and 3.94 (95% CI, 1.89-8.22, P<0.001), respectively, after adjustment for confounding factors. CONCLUSION: Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of > or = 90 cm in men and > or = 80 cm in women is a better predictor of each ischemic stroke subtype in the Japanese population. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Angelo Scuteri; Pedro G Cunha; E Agabiti Rosei; Jolita Badariere; Sofie Bekaert; John R Cockcroft; Jorge Cotter; Francesco Cucca; Marc L De Buyzere; Tim De Meyer; Luigi Ferrucci; Osca Franco; Nichola Gale; Thierry C Gillebert; A Hofman; Michel Langlois; Aleksandras Laucevicius; Stephane Laurent; Francesco U S Mattace Raso; Cristopher H Morrell; Maria Lorenza Muiesan; Margaret M Munnery; Rokas Navickas; Pedro Oliveira; Marco Orru'; Maria Grazia Pilia; Ernst R Rietzschel; Ligita Ryliskyte; Massimo Salvetti; David Schlessinger; Nuno Sousa; Christodoulos Stefanadis; James Strait; Caroline Van Daele; Isabel Villa; Charalambos Vlachopoulos; Jacqueline Witteman; Panagiotis Xaplanteris; Peter Nilsson; Edward G Lakatta Journal: Atherosclerosis Date: 2014-01-30 Impact factor: 5.162