Literature DB >> 19941910

The role of formins in human disease.

Aaron D DeWard1, Kathryn M Eisenmann, Stephen F Matheson, Arthur S Alberts.   

Abstract

Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis.

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Year:  2009        PMID： 19941910     DOI： 10.1016/j.bbamcr.2009.11.006

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  26 in total

1.  The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

Authors:  Keith R Anderson; Ruth A Singer; Dina A Balderes; Laura Hernandez-Lagunas; Christopher W Johnson; Kristin B Artinger; Lori Sussel
Journal:  Development       Date:  2011-08       Impact factor: 6.868

Review 2.  Nucleating actin for invasion.

Authors:  Alexander Nürnberg; Thomas Kitzing; Robert Grosse
Journal:  Nat Rev Cancer       Date:  2011-02-10       Impact factor: 60.716

3.  Dissection of two parallel pathways for formin-mediated actin filament elongation.

Authors:  Laura A Sherer; Mark E Zweifel; Naomi Courtemanche
Journal:  J Biol Chem       Date:  2018-09-28       Impact factor: 5.157

4.  Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila.

Authors:  Cynthia J Schoen; Sarah B Emery; Marc C Thorne; Hima R Ammana; Elzbieta Sliwerska; Jameson Arnett; Michael Hortsch; Frances Hannan; Margit Burmeister; Marci M Lesperance
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

5.  The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions.

Authors:  Tsukasa Shibue; Mary W Brooks; M Fatih Inan; Ferenc Reinhardt; Robert A Weinberg
Journal:  Cancer Discov       Date:  2012-05-18       Impact factor: 39.397

6.  Septin-containing barriers control the differential inheritance of cytoplasmic elements.

Authors:  Alan Michael Tartakoff; Ilya Aylyarov; Purnima Jaiswal
Journal:  Cell Rep       Date:  2012-12-27       Impact factor: 9.423

7.  Fertility and polarized cell growth depends on eIF5A for translation of polyproline-rich formins in Saccharomyces cerevisiae.

Authors:  Tianlu Li; Borja Belda-Palazón; Alejandro Ferrando; Paula Alepuz
Journal:  Genetics       Date:  2014-06-11       Impact factor: 4.562

8.  Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways.

Authors:  Fatouma Touré; Günter Fritz; Qing Li; Vivek Rai; Gurdip Daffu; Yu Shan Zou; Rosa Rosario; Ravichandran Ramasamy; Arthur S Alberts; Shi Fang Yan; Ann Marie Schmidt
Journal:  Circ Res       Date:  2012-04-17       Impact factor: 17.367

Review 9.  Glycation & the RAGE axis: targeting signal transduction through DIAPH1.

Authors:  Alexander Shekhtman; Ravichandran Ramasamy; Ann Marie Schmidt
Journal:  Expert Rev Proteomics       Date:  2016-12-22       Impact factor: 3.940

10.  Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.

Authors:  Xinyan Jiao; Bo Wang; Chen Feng; Shaoran Song; Bixia Tian; Can Zhou; Xiaoqian Gao; Wei Sun; Peijun Liu
Journal:  BMC Cancer       Date:  2021-06-30       Impact factor: 4.430
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