| Literature DB >> 19941890 |
Jing Han1, Ziyou Zhou, Ruixue Yin, Dongzhi Yang, Jun Nie.
Abstract
Porous scaffolds composed of alginate (AG) and chitosan (CS) were fabricated by combining the formation of polyelectrolyte complex (PEC) with freeze-drying. The AG scaffold was used as a framework with uniformly distributed and interconnected pore structure. The chitosan or chitosan/hydroxyapatite (CS/HA) composite solution was introduced into the pores of AG scaffold to form PEC scaffolds. FT-IR, XRD and XPS analysis confirmed that CS or CS/HA was coated on the AG scaffold surface. Microstructure, porosity, mechanical strength and thermal stability of PEC scaffolds were also investigated. The AG-CS PEC scaffold and Ca2+ crosslinked AG scaffold showed smaller average pore diameter and lower porosity than those of uncrosslinked AG scaffold. Moreover, compared with Ca2+ crosslinked AG scaffold, AG-CS PEC scaffold exhibited higher mechanical strength and better thermal stability. 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19941890 DOI： 10.1016/j.ijbiomac.2009.11.004
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953