Literature DB >> 19941407

Accelerated degradation of ibuprofen in tablets.

Wendy Clevenger Cory1, Corbyn Harris, Sabrina Martinez.   

Abstract

The forced degradation of 11 ibuprofen tablet brands was carried out according to current industry best practices. The results indicated an incompatibility between ibuprofen and two common tablet excipients (polyethylene glycol and polysorbate 80) that were observed to accelerate the degradation of ibuprofen in tablets stored for three weeks at 70°C/75% RH. Studies of binary drug/excipient samples supported the conclusion. One degradant that was observed at increased levels was 4-isobutylacetophenone (4-IBAP), which is a known toxin.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19941407     DOI： 10.3109/10837450903426518

Source DB:  PubMed          Journal:  Pharm Dev Technol        ISSN： 1083-7450            Impact factor:   3.133


  3 in total

1.  Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station.

Authors:  Virginia E Wotring
Journal:  AAPS J       Date:  2015-11-06       Impact factor: 4.009

2.  On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?

Authors:  Mohammad A Azad; Juan G Osorio; Allison Wang; David M Klee; Mary E Eccles; Erin Grela; Rebecca Sloan; Gregory Hammersmith; Kersten Rapp; David Brancazio; Allan S Myerson
Journal:  Pharm Res       Date:  2019-10-24       Impact factor: 4.200

3.  Photocatalytic degradation of ibuprofen using titanium oxide: insights into the mechanism and preferential attack of radicals.

Authors:  Maicon Oliveira Miranda; Wesley Eulálio Cabral Cavalcanti; Felipe Fernandes Barbosa; José Antonio de Sousa; Francisco Ivan da Silva; Sibele B C Pergher; Tiago Pinheiro Braga
Journal:  RSC Adv       Date:  2021-08-16       Impact factor: 3.361
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.