| Literature DB >> 19941103 |
Tewfik Miloud1, Günter J Hämmerling, Natalio Garbi.
Abstract
Dendritic cells (DCs) are key coordinators of the immune response, governing the choice between tolerance and immunity. DCs are professional antigen-presenting cells capable of presenting antigen on MHC molecules and priming CD4 and CD8 T-cell responses. They form a heterogeneous group of cells based on phenotype, location, and function. In this review, murine DCs will be discussed regarding their function with special emphasis on their tissue distribution. Recent findings on DC homeostasis during cancer progression will be presented. Finally, the developmental pathways leading to DC differentiation from their precursors will be summarized.Entities:
Mesh：
Year: 2010 PMID： 19941103 DOI： 10.1007/978-1-60761-421-0_2
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745