Literature DB >> 19941092

Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240.

Adam W Barb1, Ling Jiang, Christian R H Raetz, Pei Zhou.   

Abstract

The UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase LpxC catalyzes the committed reaction of lipid A biosynthesis, an essential pathway in Gram-negative bacteria. We report the backbone resonance assignments of the 34 kDa LpxC from Escherichia coli in complex with the antibiotic L-161,240 using multidimensional, multinuclear NMR experiments. The (1)H chemical shifts of complexed L-161,240 are also determined.

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Year:  2009        PMID： 19941092      PMCID： PMC3631426          DOI： 10.1007/s12104-009-9201-5

Source DB:  PubMed          Journal:  Biomol NMR Assign        ISSN： 1874-270X            Impact factor:   0.746


  15 in total

1.  PACES: Protein sequential assignment by computer-assisted exhaustive search.

Authors:  Brian E Coggins; Pei Zhou
Journal:  J Biomol NMR       Date:  2003-06       Impact factor: 2.835

2.  Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

Authors:  Brian E Coggins; Xuechen Li; Amanda L McClerren; Ole Hindsgaul; Christian R H Raetz; Pei Zhou
Journal:  Nat Struct Biol       Date:  2003-08

3.  The C-terminal end of LpxC is required for degradation by the FtsH protease.

Authors:  Frank Führer; Sina Langklotz; Franz Narberhaus
Journal:  Mol Microbiol       Date:  2006-02       Impact factor: 3.501

4.  Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.

Authors:  Igor Mochalkin; John D Knafels; Sandra Lightle
Journal:  Protein Sci       Date:  2008-03       Impact factor: 6.725

5.  The program XEASY for computer-supported NMR spectral analysis of biological macromolecules.

Authors:  C Bartels; T H Xia; M Billeter; P Güntert; K Wüthrich
Journal:  J Biomol NMR       Date:  1995-07       Impact factor: 2.835

6.  Antibacterial agents that inhibit lipid A biosynthesis.

Authors:  H R Onishi; B A Pelak; L S Gerckens; L L Silver; F M Kahan; M H Chen; A A Patchett; S M Galloway; S A Hyland; M S Anderson; C R Raetz
Journal:  Science       Date:  1996-11-08       Impact factor: 47.728

7.  NMRPipe: a multidimensional spectral processing system based on UNIX pipes.

Authors:  F Delaglio; S Grzesiek; G W Vuister; G Zhu; J Pfeifer; A Bax
Journal:  J Biomol NMR       Date:  1995-11       Impact factor: 2.835

8.  Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

Authors:  Brian E Coggins; Amanda L McClerren; Ling Jiang; Xuechen Li; Johannes Rudolph; Ole Hindsgaul; Christian R H Raetz; Pei Zhou
Journal:  Biochemistry       Date:  2005-02-01       Impact factor: 3.162

Review 9.  Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

Authors:  Adam W Barb; Pei Zhou
Journal:  Curr Pharm Biotechnol       Date:  2008-02       Impact factor: 2.837

10.  Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.

Authors:  Adam W Barb; Ling Jiang; Christian R H Raetz; Pei Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-19       Impact factor: 11.205
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  2 in total

1.  Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.

Authors:  Chul-Jin Lee; Xiaofei Liang; Ramesh Gopalaswamy; Javaria Najeeb; Eugene D Ark; Eric J Toone; Pei Zhou
Journal:  ACS Chem Biol       Date:  2013-10-31       Impact factor: 5.100

2.  Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all gram-negative bacteria.

Authors:  Sina Langklotz; Michael Schäkermann; Franz Narberhaus
Journal:  J Bacteriol       Date:  2010-12-30       Impact factor: 3.490
  2 in total

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