BACKGROUND: The objective of this study was to examine the epidemiology of syphilis among high-risk socially marginalized populations in urban, coastal Peru, to quantify the prevalence of recent syphilis infection and identify risk factors. METHODS: Survey data and serologic specimens were collected from a population-based sample of 3 populations: men who have sex with only men (MSOM), socially marginalized heterosexual men, and socially marginalized women. Syphilis prevalence was determined for each population, and multivariate analysis was used to analyze risk factors for recent syphilis infection among the MSOM and among the socially marginalized men. RESULTS: The prevalence of recent syphilis infection was 10.5% among the MSOM, 1.5% among the socially marginalized men, and 2.0% among the women. Among both MSOM and the socially marginalized men, recent syphilis infection was significantly associated with Herpes simplex virus Type 2 infection (prevalence ratio = 1.96; 95% confidence interval, 1.03-3.74, and PR = 3.72; 95% CI, 2.12-6.53, respectively). Recent syphilis infection was also significantly associated with HIV infection among the socially marginalized men (PR = 11.13; 95% CI, 4.50-27.51) and with the number of sexually active years among the MSOM (PR = 1.05, 95% CI, 1.01-1.10). CONCLUSIONS: All 3 groups included in this study exhibited a high prevalence of recent syphilis infection, with recent infection being most prevalent among the MSOM. These findings demonstrate the need for more effective syphilis control services among those populations, to decrease syphilis-associated morbidity, transmission of syphilis, and the potential transmission of HIV.
BACKGROUND: The objective of this study was to examine the epidemiology of syphilis among high-risk socially marginalized populations in urban, coastal Peru, to quantify the prevalence of recent syphilis infection and identify risk factors. METHODS: Survey data and serologic specimens were collected from a population-based sample of 3 populations: men who have sex with only men (MSOM), socially marginalized heterosexual men, and socially marginalized women. Syphilis prevalence was determined for each population, and multivariate analysis was used to analyze risk factors for recent syphilis infection among the MSOM and among the socially marginalized men. RESULTS: The prevalence of recent syphilis infection was 10.5% among the MSOM, 1.5% among the socially marginalized men, and 2.0% among the women. Among both MSOM and the socially marginalized men, recent syphilis infection was significantly associated with Herpes simplex virus Type 2infection (prevalence ratio = 1.96; 95% confidence interval, 1.03-3.74, and PR = 3.72; 95% CI, 2.12-6.53, respectively). Recent syphilis infection was also significantly associated with HIV infection among the socially marginalized men (PR = 11.13; 95% CI, 4.50-27.51) and with the number of sexually active years among the MSOM (PR = 1.05, 95% CI, 1.01-1.10). CONCLUSIONS:All 3 groups included in this study exhibited a high prevalence of recent syphilis infection, with recent infection being most prevalent among the MSOM. These findings demonstrate the need for more effective syphilis control services among those populations, to decrease syphilis-associated morbidity, transmission of syphilis, and the potential transmission of HIV.
Authors: Stephen Tabet; Jorge Sanchez; Javier Lama; Pedro Goicochea; Pablo Campos; Manuel Rouillon; Jose Luis Cairo; Lucia Ueda; Douglas Watts; Connie Celum; King K Holmes Journal: AIDS Date: 2002-06-14 Impact factor: 4.177
Authors: Kate Buchacz; Pragna Patel; Melanie Taylor; Peter R Kerndt; Robert H Byers; Scott D Holmberg; Jeffrey D Klausner Journal: AIDS Date: 2004-10-21 Impact factor: 4.177
Authors: H Grosskurth; F Mosha; J Todd; E Mwijarubi; A Klokke; K Senkoro; P Mayaud; J Changalucha; A Nicoll; G ka-Gina Journal: Lancet Date: 1995-08-26 Impact factor: 79.321
Authors: Lao-Tzu Allan-Blitz; M Christina Herrera; Gino M Calvo; Silver K Vargas; Carlos F Caceres; Jeffrey D Klausner; Kelika A Konda Journal: AIDS Behav Date: 2019-04
Authors: T H Holtz; W Wimonsate; P A Mock; S Pattanasin; W Chonwattana; W Thienkrua; W Sukwicha; M E Curlin; A Chitwarakorn; E F Dunne Journal: Int J STD AIDS Date: 2019-01-09 Impact factor: 1.359
Authors: Angela M Bayer; Mijail Garvich; David A Díaz; Hugo Sánchez; Patricia J García; Thomas J Coates Journal: Sex Transm Infect Date: 2014-01-03 Impact factor: 3.519
Authors: Rostislav Castillo; Kelika A Konda; Segundo R Leon; Alfonso Silva-Santisteban; Ximena Salazar; Jeffrey D Klausner; Thomas J Coates; Carlos F Cáceres Journal: J Acquir Immune Defic Syndr Date: 2015-08-15 Impact factor: 3.731
Authors: Cornelis A Rietmeijer; More Mungati; Peter H Kilmarx; Beth Tippett Barr; Elizabeth Gonese; Ranmini S Kularatne; David A Lewis; Jeffrey D Klausner; Luanne Rodgers; H Hunter Handsfield Journal: Sex Transm Dis Date: 2019-09 Impact factor: 2.830
Authors: Adriana R Cruz; Allan Pillay; Ana V Zuluaga; Lady G Ramirez; Jorge E Duque; Gloria E Aristizabal; Mary D Fiel-Gan; Roberto Jaramillo; Rodolfo Trujillo; Carlos Valencia; Linda Jagodzinski; David L Cox; Justin D Radolf; Juan C Salazar Journal: PLoS Negl Trop Dis Date: 2010-05-18
Authors: Andres Maiorana; Susan Kegeles; Ximena Salazar; Kelika Konda; Alfonso Silva-Santisteban; Carlos Cáceres Journal: Glob Public Health Date: 2016-03-28
Authors: César P Cárcamo; Pablo E Campos; Patricia J García; James P Hughes; Geoff P Garnett; King K Holmes Journal: Lancet Infect Dis Date: 2012-08-08 Impact factor: 25.071
Authors: Amaya G Perez-Brumer; Kelika A Konda; H Javier Salvatierra; Eddy R Segura; Eric R Hall; Silvia M Montano; Thomas J Coates; Jeff D Klausner; Carlos F Caceres; Jesse L Clark Journal: PLoS One Date: 2013-04-25 Impact factor: 3.240