OBJECTIVE: The objective was to determine whether diffusion-weighted imaging (DWI) might be useful in differentiating uterine leiomyomas exhibiting hyperintensity on T2-weighted images from malignant lesions. METHODS: Thirty-four uterine myometrial lesions including 7 malignant tumors and 27 leiomyomas (6 cellular leiomyomas [CLM] and 21 degenerated leiomyomas [DLM]) were evaluated. The apparent diffusion coefficients (ADC) in cellular portions of the lesions were measured (10(-3) mm2/s). RESULTS: All malignant tumors showed high signal intensity on DWI with low ADC (mean [SD], 0.79 [0.26]), which was significantly lower (P < 0.01) than that in benign leiomyomas (1.51 [0.33]). The ADC in CLM (1.18 [0.16]) was significantly lower (P < 0.01) than that in DLM (1.60 [0.30]) and higher (P < 0.05) than that in malignant tumors. CONCLUSIONS: It was difficult to differentiate malignant tumors from leiomyomas on the basis of signal intensity on DWI; however, the ADC measurement may be helpful to distinguish malignant tumors, CLM, and DLM.
OBJECTIVE: The objective was to determine whether diffusion-weighted imaging (DWI) might be useful in differentiating uterine leiomyomas exhibiting hyperintensity on T2-weighted images from malignant lesions. METHODS: Thirty-four uterine myometrial lesions including 7 malignant tumors and 27 leiomyomas (6 cellular leiomyomas [CLM] and 21 degenerated leiomyomas [DLM]) were evaluated. The apparent diffusion coefficients (ADC) in cellular portions of the lesions were measured (10(-3) mm2/s). RESULTS: All malignant tumors showed high signal intensity on DWI with low ADC (mean [SD], 0.79 [0.26]), which was significantly lower (P < 0.01) than that in benign leiomyomas (1.51 [0.33]). The ADC in CLM (1.18 [0.16]) was significantly lower (P < 0.01) than that in DLM (1.60 [0.30]) and higher (P < 0.05) than that in malignant tumors. CONCLUSIONS: It was difficult to differentiate malignant tumors from leiomyomas on the basis of signal intensity on DWI; however, the ADC measurement may be helpful to distinguish malignant tumors, CLM, and DLM.
Authors: Muhammad O Awiwi; Mohamed Badawy; Akram M Shaaban; Christine O Menias; Jeanne M Horowitz; Moataz Soliman; Corey T Jensen; Ayman H Gaballah; Juan J Ibarra-Rovira; Myra K Feldman; Mindy X Wang; Peter S Liu; Khaled M Elsayes Journal: Abdom Radiol (NY) Date: 2022-05-13
Authors: Veronica Celli; Miriam Dolciami; Roberta Ninkova; Giada Ercolani; Stefania Rizzo; Maria Grazia Porpora; Carlo Catalano; Lucia Manganaro Journal: Int J Environ Res Public Health Date: 2022-05-11 Impact factor: 4.614