| Literature DB >> 19939521 |
Concepción Alvarez1, Raquel Alvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde.
Abstract
A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by the 2,3,4-trimethoxyphenyl arrangement), B-ring (N-alkyl-5-indolyl) and conversion of the Oxygen keto group into a substituted nitrogen (oximes, hydrazones, and their acetylderivatives). The conjunction of all this changes greatly diminishes the antimitotic and antiproliferative activities, but the maintenance of the keto bridge produces a potent analogue with the unusual 2,3,4-trimethoxyphenyl moiety. Copyright 2009 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2009 PMID： 19939521 DOI： 10.1016/j.ejmech.2009.10.047
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514